Lessons from 20 years with COX‐2 inhibitors: Importance of dose–response considerations and fair play in comparative trials

CO Stiller, P Hjemdahl - Journal of Internal Medicine, 2022 - Wiley Online Library
Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase (COX),
which forms prostaglandins involved in pain and inflammation. COX inhibitors have …

[HTML][HTML] Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage

C Sostres, CJ Gargallo, A Lanas - Arthritis research & therapy, 2013 - Springer
NSAIDs are among the most commonly used drugs worldwide and their beneficial
therapeutic properties are thoroughly accepted. However, they are also associated with …

Рациональное использование нестероидных противовоспалительных препаратов. Клинические рекомендации

АЕ Каратеев, ЕЛ Насонов… - Научно …, 2018 - rsp.mediar-press.net
Аннотация В 2015 г. экспертами, представляющими различные врачебные ассоциации
России, были разработаны клинические рекомендации «Рациональное применение …

Pharmacological management of persistent pain in older persons

American Geriatrics Society Panel on the … - Pain …, 2009 - academic.oup.com
Pain is a complex phenomenon caused by noxious sensory stimuli or neuropathological
mechanisms. An individual's memories, expectations, and emotions modify the experience …

Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract

C Sostres, CJ Gargallo, MT Arroyo, A Lanas - Best practice & research …, 2010 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely prescribed
medication in the world. Their main benefit derives from their anti-inflammatory and …

[HTML][HTML] A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity

PG Conaghan - Rheumatology international, 2012 - Springer
Non-steroidal anti-inflammatory drugs (NSAIDs) represent a diverse class of drugs and are
among the most commonly used analgesics for arthritic pain worldwide, though long-term …

Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review

S Bacchi, P Palumbo, A Sponta… - Anti-Inflammatory & …, 2012 - ingentaconnect.com
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated
compounds with some common therapeutic actions and side effects. They have potent anti …

[HTML][HTML] Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике»

АЕ Каратеев, ЕЛ Насонов, НН Яхно… - Современная …, 2015 - cyberleninka.ru
НПВП эффективны и удобны в использовании, однако они далеко не безопасны–
прием этих препаратов в ряде случаев может приводить к развитию серьезных …

Gastric mucosal defense and cytoprotection: bench to bedside

L Laine, K Takeuchi, A Tarnawski - Gastroenterology, 2008 - Elsevier
The gastric mucosa maintains structural integrity and function despite continuous exposure
to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue …

NSAID induced gastrointestinal damage and designing GI-sparing NSAIDs

G García-Rayado, M Navarro… - Expert review of clinical …, 2018 - Taylor & Francis
NSAIDs are widely used to treat pain and rheumatic conditions, but they induce adverse
events in different body systems, although the major, most frequent events occur in the …