Chronic myeloid leukaemia

JF Apperley - The Lancet, 2015 - thelancet.com
In less than 10 years, the prognosis of chronic myeloid leukaemia has changed from that of
a fatal disease to a disorder amenable simply to lifelong oral medication and compatible …

Haematopoietic cell transplantation as immunotherapy

FR Appelbaum - Nature, 2001 - nature.com
The graft-versus-tumour effect seen after allogeneic (genetically different) haematopoietic
cell transplantation for human malignancies represents the clearest example of the power of …

[HTML][HTML] Defining the intensity of conditioning regimens: working definitions

A Bacigalupo, K Ballen, D Rizzo, S Giralt… - Biology of blood and …, 2009 - Elsevier
Defining conditioning regimen intensity has become a critical issue for the hemopoietic stem
cell transplant (HSCT) community. In the present report we propose to define conditioning …

[HTML][HTML] Reduced-intensity conditioning regimen workshop: defining the dose spectrum. Report of a workshop convened by the center for international blood and …

S Giralt, K Ballen, D Rizzo, A Bacigalupo… - Biology of Blood and …, 2009 - Elsevier
During the 2006 BMT Tandem Meetings, a workshop was convened by the Center for
International Blood and Marrow Transplant Research (CIBMTR) to discuss conditioning …

Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects

PA McSweeney, D Niederwieser… - Blood, The Journal …, 2001 - ashpublications.org
Toxicities have limited the use of allogeneic hematopoietic cell transplantation (HCT) to
younger, medically fit patients. In a canine HCT model, a combination of postgrafting …

Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation

C Schmid, M Labopin, A Nagler… - Blood, The Journal …, 2012 - ashpublications.org
Because information on management and outcome of AML relapse after allogeneic
hematopoietic stem cell transplantation (HSCT) with reduced intensity conditioning (RIC) is …

Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation

R Childs, A Chernoff, N Contentin… - … England Journal of …, 2000 - Mass Medical Soc
Background Since allogeneic stem-cell transplantation can induce curative graft-versus-
leukemia reactions in patients with hematologic cancers, we sought to induce analogous …

Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL …

P Dreger, H Döhner, M Ritgen… - Blood, The Journal …, 2010 - ashpublications.org
The purpose of this prospective multicenter phase 2 trial was to investigate the long-term
outcome of reduced-intensity conditioning allogeneic stem cell transplantation (alloSCT) in …

Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX

AM Krackhardt, M Witzens, S Harig… - Blood, The Journal …, 2002 - ashpublications.org
Chronic lymphocytic leukemia (CLL) is associated with a variety of immunologic
disturbances. Hypogammaglobulinemia and autoimmune phenomena are both often …

Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation

M Mielcarek, PJ Martin, W Leisenring, MED Flowers… - Blood, 2003 - ashpublications.org
It is unknown whether the severity, timing, and quality of graft-versus-host disease (GVHD)
may be different after nonmyeloablative as compared with myeloablative hematopoietic …