In this review, the basic concepts and applications of design of experiments (DoE) in
recombinant protein biotechnology will be discussed. The production of recombinant …

Structure-based drug design (SBDD) heavily relies on the production of high-resolution (<
2Å) three-dimensional (3D) structures of the drug target in the presence or absence of the …

Among its attributes, the mythical philosopher's stone is supposedly capable of turning base
metals to gold or silver. In an analogous fashion, we are finding that protein crystallization …

Background Large number of features are extracted from protein crystallization trial images
to improve the accuracy of classifiers for predicting the presence of crystals or phases of the …

The data representation as well as naming conventions used in commercial screen files by
different companies make the automated analysis of crystallization experiments difficult and …

Multimedia information retrieval has been a challenging problem due to the diversity and
size of multimedia data along with difficulty of expressing desired queries. This paper …

Obtaining diffraction‐quality crystals is still a bottleneck for biomacromolecular structure
determination using X‐ray diffraction. In practice, the bottleneck mainly comprises two …

Protein crystallization is the process of formation of protein crystals. Many combinations of
chemicals need to be tried to obtain a crystal for some difficult proteins. This paper discusses …

Protein crystallization screening focuses on determining the factors crucial for successful
protein crystallization. Protein crystallization may require large number of parameters to be …

In high-throughput systems, the crystallization experiments require the inspection and
analysis of a large number of trial images. The visualization and analysis tools are needed …