[HTML][HTML] Tumoral heterogeneity in neuroblastoma

RL Gomez, S Ibragimova, R Ramachandran… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …

Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis

IS Fetahu, W Esser-Skala, R Dnyansagar… - Nature …, 2023 - nature.com
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …

Schwann cell-derived exosomal vesicles: a promising therapy for the injured spinal cord

M Ghosh, DD Pearse - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular
milieu. Within these nanovesicles reside a multitude of bioactive molecules, which …

Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion

S Deborde, L Gusain, A Powers, A Marcadis, Y Yu… - Cancer discovery, 2022 - AACR
Nerves are a component of the tumor microenvironment contributing to cancer progression,
but the role of cells from nerves in facilitating cancer invasion remains poorly understood …

Spatial and transcriptomic analysis of perineural invasion in oral cancer

LB Schmitd, C Perez-Pacheco, EL Bellile, W Wu… - Clinical Cancer …, 2022 - AACR
Abstract Purpose: Perineural invasion (PNI), a common occurrence in oral squamous cell
carcinomas, is associated with poor survival. Consequently, these tumors are treated …

Marriage of High‐Throughput Gradient Surface Generation With Statistical Learning for the Rational Design of Functionalized Biomaterials

Z Fang, M Zhang, H Wang, J Chen, H Yuan… - Advanced …, 2023 - Wiley Online Library
Functional biomaterial is already an important aspect in modern therapeutics; yet, the design
of novel multi‐functional biomaterial is still a challenging task nowadays. When several …

[HTML][HTML] Schwann cells contribute to keloid formation

M Direder, T Weiss, D Copic, V Vorstandlechner… - Matrix Biology, 2022 - Elsevier
Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms,
which could lead to severe functional impairments. Here we analyzed the characteristics of …

Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities

R Malik, N Beaufort, S Frerich, B Gesierich… - Brain, 2021 - academic.oup.com
White matter hyperintensities (WMH) are among the most common radiological
abnormalities in the ageing population and an established risk factor for stroke and …

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation

B de Jonckheere, F Kollotzek, P Münzer… - Nature cardiovascular …, 2023 - nature.com
During megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes
with strong modification of membrane composition and lipid signaling. Here, we adopt a lipid …

Landscape of bone marrow metastasis in human neuroblastoma unraveled by transcriptomics and deep multiplex imaging

D Lazic, F Kromp, F Rifatbegovic, P Repiscak, M Kirr… - Cancers, 2021 - mdpi.com
Simple Summary Bone marrow metastasis frequently occurs in patients with solid cancers
and most often leads to poor outcome. Yet, the composition of bone marrow metastases …