• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Abstract Background Vancomycin‑resistant Staphylococcus aureus (VRSA) is a serious
public health challenging concern worldwide. Objectives Therefore, the objective of present …

Importance Practice guidelines often provide recommendations in which the strength of the
recommendation is dissociated from the quality of the evidence. Objective To create a …

Importance Cefepime and piperacillin-tazobactam are commonly administered to
hospitalized adults for empirical treatment of infection. Although piperacillin-tazobactam has …

Complicated community-acquired pneumonia in a previously well child is a severe illness
characterised by combinations of local complications (eg, parapneumonic effusion …

Staphylococcus aureus frequently causes infections that are challenging to treat, leading to
high rates of persistent and relapsing infection. Here, to understand how the host …

Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious
disease, with a 90-day mortality of 15%–30%. Despite this,< 3000 people have been …

Key Clinical Points Native-Valve Infective Endocarditis The modified Duke criteria, which are
based on findings on physical examination, echocardiography, microbiologic studies, and …

Background We aimed to determine whether daptomycin plus fosfomycin provides higher
treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus …

Staphylococcus aureus bacteremia (SaB) causes significant disease in humans, carrying
mortality rates of∼ 25%. The ability to rapidly predict SaB patient responses and guide …