Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenesis by …

Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

INTRODUCTION Immunoglobulin A (IgA) is the most abundant mammalian antibody
isotype, constituting more than 80% of all antibody-secreting plasma cells at steady state …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

Autoimmune reactions reflect an imbalance between effector and regulatory immune
responses, typically develop through stages of initiation and propagation, and often show …

Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in
individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune …

Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …