Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific
biological information and have progressively emerged as key regulators of organized …

Obesity is a global pandemic associated with macro-and microvascular endothelial
dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk …

High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive
and emotional dysfunctions that constitute a sizeable worldwide health burden with …

Overnutrition and modern diets containing high proportions of saturated fat are among the
major factors contributing to a low-grade state of inflammation, hyperglycemia and …

The metabolic dysfunctions induced by high fat diet (HFD) consumption are not limited to
organs involved in energy metabolism but cause also a chronic low-grade systemic …

Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates
cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating …

In recent decades, traditional eating habits have been replaced by a more globalized diet,
rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary …

As resident component of the innate immunity in the central nervous system (CNS),
microglia are key players in pathology. However, they also exert fundamental roles in brain …

High-caloric diet and physical inactivity predispose individuals to obesity and diabetes,
which are risk factors of hippocampal neurodegeneration and cognitive deficits. Along with …

Increased life expectancy in combination with modern life style and high prevalence of
obesity are important risk factors for development of neurodegenerative diseases …