Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery
In spite of the availability of a large number of anti-inflammatory and analgesic agents,
fighting pain and inflammation remains a common problem. The current review article …
fighting pain and inflammation remains a common problem. The current review article …
A series of new hydrazone derivatives: Synthesis, molecular docking and anticholinesterase activity studies
Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to
be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is …
be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is …
Synthesis of novel antipyrine-azole-S-alkyl derivatives antimicrobial activity, molecular docking, and computational studies
In this investigation, we synthesized the newly antipyrine-azole-S-alkyl and their reduction
derivatives that were screened for their antimicrobial activity and compared them with …
derivatives that were screened for their antimicrobial activity and compared them with …
New pyrazole–pyridazine hybrids as selective COX-2 inhibitors: design, synthesis, molecular docking, in silico studies and investigation of their anti-inflammatory …
Hybrid-based design has gained significant interest in the development of novel active
substances with anti-inflammatory properties. In this study, two series of new pyrazole …
substances with anti-inflammatory properties. In this study, two series of new pyrazole …
Synthesis, structural characterisation and theoretical studies of a novel pyridazine derivative: Investigations of anti-inflammatory activity and inhibition of α-glucosidase
X-ray crystallography on pyridazine 1 (ethyl 2-(3-methyl-4-(4-methylbenzyl)-6-oxopyridazin-
1 (6H)-yl) acetate) shows the planar pyridazinyl ring to exhibit significant delocalisation of π …
1 (6H)-yl) acetate) shows the planar pyridazinyl ring to exhibit significant delocalisation of π …
Synthesis, molecular structure, spectral characterization, and biological activities of ethyl 2-(4-(4-chlorobenzyl)-3-methyl-6-oxopyridazin-1 (6H)-yl) acetate
The structure of the ethyl 2-(4-(4-chlorobenzyl)-3-methyl-6-oxopyridazin-1 (6H)-yl) acetate
(COAP) was revealed using single crystal X-ray diffraction method, was solved and refined …
(COAP) was revealed using single crystal X-ray diffraction method, was solved and refined …
Synthesis of potent vasodilating agents: in silico and in vitro evaluation of 6-(4-substitutedphenyl)-3-pyridazinone derivatives as potential hydralazine analogues
People of all age categories and lifestyles suffer to different extents from hypertension.
Accordingly, this necessitates the rise of new ways to defeat this enemy. Vasodilators exert a …
Accordingly, this necessitates the rise of new ways to defeat this enemy. Vasodilators exert a …
Applications and biological potential of substituted pyridazine analogs in medicinal and agricultural fields
M Asif, M Allahyani, MM Almehmadi… - Current Organic …, 2023 - benthamdirect.com
Pyridazine derivatives are an important heterocyclic family in medication development.
Because of their biological relevance, there has been a surge in interest in the chemistry of …
Because of their biological relevance, there has been a surge in interest in the chemistry of …
Design, synthesis and biological evaluation of novel 1, 3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents
With the aim of achieving new compounds possessing both anti-inflammatory and
antiplatelet activities, we synthesized (E)-3-[3-(pyridin-3/4-yl)-1-(phenyl …
antiplatelet activities, we synthesized (E)-3-[3-(pyridin-3/4-yl)-1-(phenyl …
Recent advances in anti-inflammatory potential of pyridazinone derivatives
M Saini, DK Mehta, R Das… - Mini Reviews in Medicinal …, 2016 - ingentaconnect.com
Pyridazinone and its derivatives have various ranges of biological and pharmacological
activities including anti-inflammatory, antifeedant, anticonvulsant, antidiabetic, herbicidal …
activities including anti-inflammatory, antifeedant, anticonvulsant, antidiabetic, herbicidal …