Correlation and association analyses in microbiome study integrating multiomics in health and disease

Y Xia - Progress in molecular biology and translational …, 2020 - Elsevier
Correlation and association analyses are one of the most widely used statistical methods in
research fields, including microbiome and integrative multiomics studies. Correlation and …

[HTML][HTML] Methodological Considerations in Longitudinal Analyses of Microbiome Data: A Comprehensive Review

R Lyu, Y Qu, K Divaris, D Wu - Genes, 2023 - mdpi.com
Biological processes underlying health and disease are inherently dynamic and are best
understood when characterized in a time-informed manner. In this comprehensive review …

Estimating and testing the microbial causal mediation effect with high-dimensional and compositional microbiome data

C Wang, J Hu, MJ Blaser, H Li - Bioinformatics, 2020 - academic.oup.com
Motivation Recent microbiome association studies have revealed important associations
between microbiome and disease/health status. Such findings encourage scientists to dive …

[HTML][HTML] Microbial trend analysis for common dynamic trend, group comparison, and classification in longitudinal microbiome study

C Wang, J Hu, MJ Blaser, H Li - BMC genomics, 2021 - Springer
Background The human microbiome is inherently dynamic and its dynamic nature plays a
critical role in maintaining health and driving disease. With an increasing number of …

[HTML][HTML] LISA2: learning complex single-cell trajectory and expression trends

Y Chen, Y Zhang, JYH Li, Z Ouyang - Frontiers in Genetics, 2021 - frontiersin.org
Single-cell transcriptional and epigenomics profiles have been applied in a variety of tissues
and diseases for discovering new cell types, differentiation trajectories, and gene regulatory …

Joint principal trend analysis for longitudinal high‐dimensional data

Y Zhang, Z Ouyang - Biometrics, 2018 - Wiley Online Library
We consider a research scenario motivated by integrating multiple sources of information for
better knowledge discovery in diverse dynamic biological processes. Given two longitudinal …

[图书][B] New approaches for unsupervised transcriptomic data analysis based on Dictionary learning

MM Rams - 2022 - search.proquest.com
The era of high-throughput data generation enables new access to biomolecular profiles
and exploitation thereof. However, the analysis of such biomolecular data, for example …

PATH: An interactive web platform for analysis of time-course high-dimensional genomic data

Y Zhang, Y Chen, Z Ouyang - International journal of …, 2020 - inderscienceonline.com
Discovering patterns in time-course genomic data can provide insights on the dynamics of
biological systems in health and disease. Here, we present a Platform for Analysis of Time …

[PDF][PDF] Predicting quantitative outcomes of patients using longitudinal gene expression

Y Zhang, Z Ouyang - Sri Lankan Journal of Applied …, 2014 - pdfs.semanticscholar.org
We present a new statistical method using longitudinal gene expression to predict
quantitative outcomes of patients. Through simulations and application on a dataset of burn …

Lagged principal trend analysis for longitudinal high‐dimensional data

Y Zhang - Stat, 2019 - Wiley Online Library
Biological systems are dynamic in nature, where time‐lagged correlations are commonly
observed. Motivated by the problem of integrating longitudinal high‐dimensional datasets …