Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key
model system for neural stem cell biology and have provided key insights into the …

The ability of cells to divide asymmetrically is essential for generating diverse cell types
during development. The past 10 years have seen tremendous progress in our …

Stem cells self-renew but also give rise to daughter cells that are committed to lineage-
specific differentiation. To achieve this remarkable task, they can undergo an intrinsically …

Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

Centrosome amplification is a common feature of many cancer cells, and it has been
previously proposed that centrosome amplification can drive genetic instability and so …

For decades, lower-model organisms such as Drosophila melanogaster have often provided
the first glimpse into the mechanism of action of human cancer-related proteins, thus making …

Asymmetric cell division is fundamental for generating diversity in multicellular organisms.
The mechanisms that govern asymmetric cell division are increasingly well understood …

In both vertebrates and insects, neurons typically arise from neural stem cells or terminally
dividing intermediate progenitors. Here, we describe another mode of neurogenesis where …

In the mouse neocortex, neural progenitor cells generate both differentiating neurons and
daughter cells that maintain progenitor fate. Here, we show that the TRIM-NHL protein …