Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …

Cancer cells reside amongst a complex milieu of stromal cells and structural features known
as the tumor microenvironment. Often cancer cells divert and co-opt functions of stromal …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

As the most aggressive tumor, the outcome of pancreatic cancer (PACA) has not improved
observably over the last decade. Anatomy-based TNM staging does not exactly identify …

The tumor microenvironment plays a crucial role in determining response to treatment. This
involves a series of interconnected changes in the cellular landscape, spatial organization …

Glioblastoma is an aggressive tumor and is associated with a dismal prognosis. The
availability of few active treatments as well as the inexorable recurrence after surgery are …

Brain tumors are the leading cause of morbidity and mortality related to cancer in children,
where high-grade glioma harbor the worst prognosis. It has become obvious that pediatric …

Tumor‐associated astrocytes (TAAs) in the glioblastoma microenvironment play an
important role in tumor development and malignant progression initiated by glioma stem …

Key molecular regulators of acquired radiation resistance in recurrent glioblastoma (GBM)
are largely unknown, with a dearth of accurate preclinical models. To address this, we …

Accumulating evidence suggests that changes in the tumor microenvironment caused by
radiotherapy are closely related to the recurrence of glioma. However, the mechanisms by …