An intact cerebellum is a prerequisite for optimal ocular motor performance. The cerebellum
fine-tunes each of the subtypes of eye movements so they work together to bring and …

Primary episodic ataxias are autosomal dominant channelopathies that manifest as attacks
of imbalance and incoordination. Mutations in two genes, KCNA1 and CACNA1A, cause the …

Multiple sclerosis (MS) is the most common disabling neurological disease in young people.
Most CNS lesions involve neuroanatomically non-eloquent zones that often do not result in …

Background Recent studies have extended our understanding of the pathophysiology,
natural course, and treatment of vestibular vertigo. The relative frequency of the different …

Purpose.: Nystagmus, which can be infantile (congenital) or acquired, affects all ages. The
prevalence of nystagmus in the general population is unknown. New genetic research and …

Abstract Treatment of motor symptoms of degenerative cerebellar ataxia remains difficult.
Yet there are recent developments that are likely to lead to significant improvements in the …

An impairment of eye movements, or nystagmus, is seen in many diseases of the central
nervous system, in particular those affecting the brainstem and cerebellum, as well as in …

Patients with episodic ataxia type 2 (EA2) can often be successfully treated with
acetazolamide. The authors report three patients with EA2 (two with proven mutations in the …

Objective: The therapeutic effects of 4-aminopyridine (4AP) were investigated in a
randomized, double-blind, crossover trial in 10 subjects with familial episodic ataxia with …

Results A careful history remains the cornerstone of diagnosis. Once the correct diagnosis is
made, specific and effective treatments are available for most peripheral, central, and …