Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …

Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …