Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …

Atherosclerosis is an inflammatory arterial pathogenic condition, which leads to ischemic
cardiovascular diseases, such as coronary artery disease and myocardial infarction, stroke …

Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy,
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …

Obesity is one of the most serious worldwide epidemics of the twenty-first century according
to the World Health Organization. Frequently associated with a number of comorbidities …

We previously showed that middle-aged female rats sustain a larger infarct following
experimental stroke as compared to younger female rats, and paradoxically, estrogen …

Cardiovascular disease is emerging as a cardinal trait of Turner syndrome, being
responsible for half of the 3-fold excess mortality. Turner syndrome has been proposed as …

Background The effects of insulin-like growth factor-1 (IGF-1) deficiency on cognitive decline
have been consistently reported in animal studies, but the relationship between IGF-1 and …