Whispering-gallery mode optoplasmonic microcavities: From advanced single-molecule sensors and microlasers to applications in synthetic biology

MC Houghton, SV Kashanian, TL Derrien… - ACS …, 2024 - ACS Publications
Optical microcavities, specifically, whispering-gallery mode (WGM) microcavities, with their
remarkable sensitivity to environmental changes, have been extensively employed as …

Protein amyloids develop an intrinsic fluorescence signature during aggregation

FTS Chan, GSK Schierle, JR Kumita, CW Bertoncini… - Analyst, 2013 - pubs.rsc.org
We report observations of an intrinsic fluorescence in the visible range, which develops
during the aggregation of a range of polypeptides, including the disease-related human …

From single-molecule spectroscopy to super-resolution imaging of the neuron: a review

RF Laine, GSK Schierle, S Van De Linde… - … and applications in …, 2016 - iopscience.iop.org
For more than 20 years, single-molecule spectroscopy has been providing invaluable
insights into nature at the molecular level. The field has received a powerful boost with the …

Detection of protein aggregate morphology through single antifouling nanopore

N Giamblanco, D Coglitore, JM Janot… - Sensors and Actuators B …, 2018 - Elsevier
In this report, we investigate the potential offered by nanopores for the detection of proteins
aggregates. We focus our study on model proteins, such as ß-lactoglobulin, lysozyme and …

Modulating amyloids' formation path with sound energy

A Kozell, D Eliaz, A Solomonov… - Proceedings of the …, 2023 - National Acad Sciences
Protein folding is crucial for biological activity. Proteins' failure to fold correctly underlies
various pathological processes, including amyloidosis, the aggregation of insoluble proteins …

Correcting chromatic offset in multicolor super-resolution localization microscopy

M Erdelyi, E Rees, D Metcalf, GSK Schierle, L Dudas… - Optics express, 2013 - opg.optica.org
Localization based super-resolution microscopy techniques require precise drift correction
methods because the achieved spatial resolution is close to both the mechanical and optical …

Probing amyloid protein aggregation with optical superresolution methods: from the test tube to models of disease

CF Kaminski, GS Kaminski Schierle - Neurophotonics, 2016 - spiedigitallibrary.org
The misfolding and self-assembly of intrinsically disordered proteins into insoluble amyloid
structures are central to many neurodegenerative diseases such as Alzheimer's and …

Molecular basis of the inhibition and disaggregation of thermally-induced amyloid fibrils of human serum albumin by an anti-Parkinson's drug, benserazide …

TI Chandel, A Masroor, MK Siddiqi, IA Siddique… - Journal of Molecular …, 2019 - Elsevier
This study summarises the results of multifactorial analysis of the inhibition/destabilization of
human serum albumin (HSA) amyloid fibrils by an anti-Parkinson's drug, benserazide …

Stability of lysozyme in aqueous extremolyte solutions during heat shock and accelerated thermal conditions

C Avanti, V Saluja, ELP Van Streun, HW Frijlink… - PLoS …, 2014 - journals.plos.org
The purpose of this study was to investigate the stability of lysozyme in aqueous solutions in
the presence of various extremolytes (betaine, hydroxyectoine, trehalose, ectoine, and firoin) …

In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer's Disease, Major Depressive Disorder, and Type 2 …

JWD Griffin, Y Liu, PC Bradshaw, K Wang - Journal of Molecular …, 2018 - Springer
Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate
metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving …