Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Coordinated function of the innate and adaptive arms of the immune system in vertebrates is
essential to promote protective immunity and to avoid immunopathology. The Notch …

The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …

Bone marrow-derived B cells make an important cell fate choice to develop into either
follicular B cells or marginal zone B cells in the spleen, which depends on signalling through …

The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

The Notch signaling pathway regulates many aspects of embryonic development, as well as
differentiation processes and tissue homeostasis in multiple adult organ systems …

To systematically investigate innate immune signaling networks regulating production of
type I interferon, we analyzed protein complexes formed after microbial recognition. Fifty …

Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and
homeostasis of immune cells. Besides, this pathway is also directly involved in the …

Ubiquitination plays a central role in the regulation of various biological functions including
immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 …

Mammalian genomes encode up to four Notch receptors (Notch1–4) and five Notch ligands
of the DSL (Delta/Serrate/Lag-2) family, and Notch signaling controls a wide spectrum of …