The role of natural products in drug discovery and development against neglected tropical diseases

PM Cheuka, G Mayoka, P Mutai, K Chibale - Molecules, 2016 - mdpi.com
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae)

NJ Toyang, R Verpoorte - Journal of ethnopharmacology, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The Vernonia genus has about one thousand
species and members of the genus are widely used as food and medicine. The aim of this …

Cameroonian medicinal plants: pharmacology and derived natural products

V Kuete, T Efferth - Frontiers in pharmacology, 2010 - frontiersin.org
Many developing countries including Cameroon have mortality patterns that reflect high
levels of infectious diseases and the risk of death during pregnancy and childbirth, in …

Natural products active against African trypanosomes: a step towards new drugs

S Hoet, F Opperdoes, R Brun… - Natural product reports, 2004 - pubs.rsc.org
Covering: mid-1980s up to June 2003 This review covers compounds with activity on African
trypanosomes (mainly Trypanosoma brucei subsp., T. congolense and T. vivax) isolated …

Natural products as trypanocidal, antileishmanial and antimalarial drugs

A Fournet, V Muñoz - Current Topics in medicinal chemistry, 2002 - benthamdirect.com
Parasitic diseases caused by protozoa as Leishmania, Trypanosome or Plasmodium are
responsible for more than three millions deaths annually throughout the developing …

Bioactive natural products derived from the Central African flora against neglected tropical diseases and HIV

D Zofou, F Ntie-Kang, W Sippl, SMN Efange - Natural Product Reports, 2013 - pubs.rsc.org
Covering: 1971 to 2013 This review discusses the medicinal potential of bioactive
metabolites isolated from medicinal plants in Central Africa for the treatment of neglected …

Compounds from African medicinal plants with activities against selected parasitic diseases: schistosomiasis, trypanosomiasis and leishmaniasis

CV Simoben, F Ntie-Kang, SH Akone… - Natural products and …, 2018 - Springer
Parasitic diseases continue to represent a threat on a global scale, particularly among the
poorest countries in the world. This is particularly because of the absence of vaccines, and …

African natural products with potential anti-trypanosomal properties: A review

L Bashir, OK Shittu, S Sani… - … Research & Review, 2015 - editor.journal7sub.com
Ethnopharmacological Relevance: Africa is considered to be the cradle of mankind with a
rich biological and cultural diversity marked regional difference in healing practices. Natural …

Acute and subacute toxicities of African medicinal plants

GN Teke, V Kuete - Toxicological survey of African medicinal plants, 2014 - Elsevier
Medicinal plants are used worldwide as an alternative and/or a complementary medicine.
Studies on these medicinal plants including pharmacological and toxicological evaluations …

The anti‐Trypanosoma activities of medicinal plants: A systematic review of the literature

S Nekoei, F Khamesipour… - Veterinary Medicine …, 2022 - Wiley Online Library
Background The existing drug treatments for trypanosomiases are limited and suffer from
shortcomings due to their toxicity and the emergence of resistant parasites. Developing anti …