Virtual compound libraries are increasingly being used in computer-assisted drug discovery
applications and have led to numerous successful cases. This paper aims to examine the …

The κ-opioid receptor (KOR) has recently emerged as an alternative therapeutic target for
the development of pain medications, without deleterious side effects associated with the μ …

Lactams are a class of compounds important for drug design, due to their great variety of
potential therapeutic applications, spanning cancer, diabetes, and infectious diseases. So …

The κ-opioid receptor (KOR) is an attractive target for the development of novel drugs. KOR
agonists are potentially safer pain medications, whereas KOR antagonists are promising …

The rising opioid crisis has become a worldwide societal and public health burden, resulting
from the abuse of prescription opioids. Targeting the κ-opioid receptor (KOR) in the …

The regeneration of enzymatic cofactors by cell‐free synthetic modules is a key step towards
producing a purely synthetic cell. Herein, we demonstrate the regeneration of the enzyme …

Aim: The pharmaceutical industry is showing renewed interest in therapeutic peptides.
Unfortunately, the chemical synthesis of peptides remains very expensive and problematic …

C-fused γ-lactam-lactones are resident in several bioactive molecules, including anticancer
agents such as omuralide. In this embodiment, we report mild conditions for the catalytic …

Kappa opioid receptor (KOR) agonists are potentially useful as analgesic and anti-pruritic
agents, for prevention and treatment of substance use disorders, and for treatment of …

μ opioid receptor (MOR) agonists have been widely applied for treating moderate to severe
pain. However, numerous adverse effects have been associated with their application …