Resistance afforded by the sickle-cell trait against severe malaria has led to high
frequencies of the sickle-cell mutation [HBB; c. 20T> A, p. Glu6Val; OMIM: 141900 (HBB-βS)] …

Sickle cell disease (SCD) is characterized by red cell sickling, tissue infarcts, pain and
haemolysis. Haemolysis leads to anaemia, transfusion and vasculopathic multi-organ …

Abstract Background Oxidative Stress, an imbalance in the pro-oxidant/antioxidant
homeostasis, occurs in many physiological and non-physiological processes and several …

Background and Objectives Sickle cell anemia (SCA) and glucose-6-phosphate
dehydrogenase (G6PD) deficiency are both hereditary diseases of the red blood cells that …

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell
disease are common genetic defects of red blood cells that lead to hemolytic anemia. The …

Background The impact of glucose-6-phosphate dehydrogenase deficiency (G-6-PD) on the
clinical course of sickle cell disease (SCD) is still controversial. The objectives of this study …

Both sickle cell anemia (SCA) and glucose-6-phosphate dehydrogenase (G6PD) deficiency
are common genetically transmitted disorders associated with hemolytic anemia, with a high …

Background: Sickle cell anaemia (SCA) and Glucose-6-phosphate dehydrogenase (G-6-PD)
deficiency are inherited red cell disorders associated with chronic haemolysis that have a …

Le déploiement du séquençage haut débit (SHD) ces dernières années au sein des
laboratoires de génétique hospitaliers en France et dans le monde a révolutionné la prise …

Sickle cell anaemia and Glucose-6-phosphate dehydrogenase deficiency have anaemia as
major clinical consequence. The two disorders are rarely co-expressed in a patient …