Simple Summary Soft tissue and bone sarcomas belong to a group of rare and malignant
tumors. The treatment of these tumors is very complex and depends on their specific …

Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma
subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a …

Due to their rarity and complexity, sarcomas represent a substantial therapeutic challenge.
However, the incredible diversity within and across sarcoma subtypes presents an …

Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable
histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas …

Purpose: The landscape of extracellular matrix (ECM) alterations in soft tissue sarcomas
(STS) remains poorly characterized. We aimed to investigate the tumor ECM and adhesion …

Targeting the DNA damage response (DDR) pathway is an emerging therapeutic approach
for leiomyosarcoma (LMS), and loss of RNase H2, a DDR pathway member, is a potentially …

Single-molecule fluorescence in situ hybridization (smFISH) represents a promising
approach for the quantitative analysis of nucleic acid biomarkers in clinical tissue samples …

Background Adolescents and young adult (AYA) patients with soft tissue tumours including
sarcomas are an underserved group with disparities in treatment outcomes. Methods To …

Angiosarcoma is a rare endothelial-derived malignancy that is extremely diverse in
anatomy, aetiology, molecular and immune characteristics. While novel therapeutic …

Angiosarcoma is a rare subtype of malignant neoplasm originating from vascular or
lymphatic endothelial cells; its low incidence has posed significant challenges for …