Background The mechanisms underlying the non-antimicrobial immunomodulatory
properties of macrolides are not well understood. Objectives To systematically review the …

Inflammation plays a critical role in cystic fibrosis (CF) lung pathology and disease
progression making it an active area of research and important therapeutic target. In this …

Azithromycin is a macrolide antibiotic which inhibits bacterial protein synthesis, quorum-
sensing and reduces the formation of biofilm. Accumulating effectively in cells, particularly …

Rationale: Cystic fibrosis (CF) is an autosomal recessive disease characterized by abnormal
airways secretions, chronic endobronchial infection, and progressive airway obstruction …

Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly
for respiratory infections. It is now recognized that these drugs, in particular azithromycin …

Importance Macrolide antibiotics have been shown beneficial in cystic fibrosis (CF) and
diffuse panbronchiolitis, and earlier findings also suggest a benefit in non-CF …

Background Azithromycin is a macrolide antibiotic with anti-inflammatory and
immunomodulatory properties. We tested the hypothesis that azithromycin would decrease …

Macrolides have diverse biological activities and an ability to modulate inflammation and
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …

Background Macrolide resistance is an increasing problem; there is therefore debate about
when to implement maintenance treatment with macrolides in patients with chronic …

Surface-attached colonies of bacteria known as biofilms play a major role in the
pathogenesis of device-related infections. Biofilm colonies are notorious for their resistance …