Current situation of viral hepatitis in Egypt

A Elbahrawy, MK Ibrahim, A Eliwa… - Microbiology and …, 2021 - Wiley Online Library
An estimated 8–10 million people suffer from viral hepatitis in Egypt. Hepatitis A virus (HAV)
and hepatitis E virus (HEV) are the major causes of viral hepatitis in Egypt as 50% or more of …

A systematic review of the current hepatitis B viral infection and hepatocellular carcinoma situation in Mediterranean countries

S Madihi, H Syed, F Lazar, A Zyad… - Biomed research …, 2020 - Wiley Online Library
Viral hepatitis B is a global public health problem affecting nearly two billion subjects; 3.3%
of whom are from the WHO (World Health Organization) Eastern Mediterranean Region …

[HTML][HTML] Changes of gut-microbiota-liver axis in hepatitis C virus infection

M El-Mowafy, A Elgaml, M El-Mesery, S Sultan… - Biology, 2021 - mdpi.com
The gut–liver-axis is a bidirectional coordination between the gut, including microbial
residents, the gut microbiota, from one side and the liver on the other side. Any disturbance …

Hepatitis B virus molecular epidemiology, host-virus interaction, coinfection, and laboratory diagnosis in the MENA region: An update

DW Al-Sadeq, SA Taleb, RE Zaied, SM Fahad… - Pathogens, 2019 - mdpi.com
Hepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause
acute and chronic hepatitis. According to the World Health Organization (WHO) and the …

HBV preS mutations promote hepatocarcinogenesis by inducing endoplasmic reticulum stress and upregulating inflammatory signaling

W Liu, S Cai, R Pu, Z Li, D Liu, X Zhou, J Yin, X Chen… - Cancers, 2022 - mdpi.com
Simple Summary Viral mutations at the preS region of hepatitis B virus (HBV) significantly
increase the risk of developing hepatocellular carcinoma (HCC). Compared to HBV preS …

Genetic diversity, haplotype analysis, and prevalence of Hepatitis B virus MHR mutations among isolates from Kenyan blood donors

BK Langat, KO Ochwedo, J Borlang, C Osiowy, A Mutai… - Plos one, 2023 - journals.plos.org
Background The rapid spread of HBV has resulted in the emergence of new variants. These
viral genotypes and variants, in addition to carcinogenic risk, can be key predictors of …

Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability

MN Amin, YM El-Far, M El-Mowafy, A Elgaml - Clinical Epigenetics, 2023 - Springer
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus
(HBV) is one of the major causes of HCC. Poor clinical outcome of HCC patients is attributed …

Mutations in the S gene of hepatitis B virus in three generations of patients with chronic hepatitis B

M Naderi, SM Hosseini, N Behnampour, I Shahramian… - Virus Genes, 2023 - Springer
Failure to neutralize HBsAg and subsequent escape from the host immune system may be
caused by HBsAg mutations, particularly in the" a" determinant, which alters the antigenicity …

[HTML][HTML] Molecular epidemiology, phylogenetic analysis and genotype distribution of hepatitis B virus in Saudi Arabia: Predominance of genotype D1

AA Al-Qahtani, MR Pourkarim, NS Trovão… - Infection, Genetics and …, 2020 - Elsevier
Despite the implementation of various vaccination programs, hepatitis B virus (HBV) poses a
considerable health problem in Saudi Arabia. Insight on HBV evolutionary history in the …

Characterization of a breakthrough vaccine escape strain associated with overt hepatitis B virus infection

M El-Mowafy, M Elegezy, M El-Mesery, A Elgaml - Virus Genes, 2024 - Springer
Hepatitis B virus (HBV) vaccine is composed of the purified hepatitis B surface antigen
(HBsAg) that is produced by recombinant DNA technology. The neutralizing antibodies …