Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

Breast cancer cells disseminate through TIE2/MENACalc/MENAINV-dependent cancer cell
intravasation sites, called tumor microenvironment of metastasis (TMEM), which are …

Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates
tumor cell invasion by affecting immune cell function, clonal cell evolution, and drug …

Studies of the role of actin in tumour progression have highlighted its key contribution in cell
softening associated with cell invasion. Here, using a human breast cell line with conditional …

Fibronectin (FN) is a major component of the tumor microenvironment, but its role in
promoting metastasis is incompletely understood. Here, we show that FN gradients elicit …

Tumors often overcome the cytotoxic effects of chemotherapy through either acquired or
environment-mediated drug resistance. In addition, signals from the microenvironment …

Clinically, increased breast tumor stiffness is associated with metastasis and poorer
outcomes. Yet, in vitro studies of tumor cells in 3D scaffolds have found decreased invasion …

The process of intravasation involving transendothelial migration is a key step in metastatic
spread. How the triple cell complex composed of a macrophage, Mena over-expressing …

Metastasis, a process that requires tumor cell dissemination followed by tumor growth, is the
primary cause of death in cancer patients. An essential step of tumor cell dissemination is …