Plants coordinately use cell‐surface and intracellular immune receptors to perceive
pathogens and mount an immune response. Intracellular events of pathogen recognition are …

The RIP homotypic interaction motif (RHIM) is a conserved protein domain that is
approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM …

Reference datasets are critical in computational biology. They help define canonical
biological features and are essential for benchmarking studies. Here, we describe a …

The gasdermin family of pore-forming proteins (PFPs) has recently emerged as key
molecular players controlling immune-related cell death in mammals. Characterized …

Investigation of fungal biology has been frequently motivated by the fact that many fungal
species are important plant and animal pathogens. Such efforts have contributed …

The viral protein ICP6, encoded by herpes simplex virus 1 (HSV-1), harbours a RIP-
homotypic interaction motif (RHIM), that plays a role in viral inhibition of host cell death …

Immune cells activate in binary, switch-like fashion via large protein assemblies known as
signalosomes, but the molecular mechanism of the switch is not yet understood. Here, we …

Diversity-generating retroelements (DGRs) are used by bacteria, archaea, and viruses as a
targeted mutagenesis tool. Through error-prone reverse transcription, DGRs introduce …

Amyloids are implicated in many protein misfolding diseases. Amyloid folds, however, also
display a range of functional roles particularly in the microbial world. The templating ability of …

NLR proteins are intracellular receptors constituting a conserved component of the innate
immune system of cellular organisms. In fungi, NLRs are characterized by high diversity of …