The incidence of idiopathic nephrotic syndrome (NS) is 1· 15–16· 9 per 100 000 children,
varying by ethnicity and region. The cause remains unknown but the pathogenesis of …

Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …

African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …

FSGS describes a renal histologic lesion with diverse causes and pathogenicities that are
linked by podocyte injury and depletion. Subclasses of FSGS include primary, genetic, and …

Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression
and, in disease research, can be particularly illuminating when using the tissues directly …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Progressive kidney diseases are often associated with scarring of the kidney's filtration unit,
a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of …

Rationale & Objectives Glomerular diseases, including minimal change disease, focal
segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) …

Damage to and loss of glomerular podocytes has been identified as the culprit lesion in
progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with …

The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is
central to the underlying pathophysiology of many common glomerular diseases, including …