Idiopathic nephrotic syndrome in children
The incidence of idiopathic nephrotic syndrome (NS) is 1· 15–16· 9 per 100 000 children,
varying by ethnicity and region. The cause remains unknown but the pathogenesis of …
varying by ethnicity and region. The cause remains unknown but the pathogenesis of …
[HTML][HTML] Focal segmental glomerulosclerosis
AZ Rosenberg, JB Kopp - Clinical Journal of the American Society …, 2017 - journals.lww.com
Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …
Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice
P Beckerman, J Bi-Karchin, ASD Park, C Qiu… - Nature medicine, 2017 - nature.com
African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …
disease, an association that is largely attributed to two common genetic variants, termed G1 …
Differentiating primary, genetic, and secondary FSGS in adults: a clinicopathologic approach
AS De Vriese, S Sethi, KA Nath… - Journal of the …, 2018 - journals.lww.com
FSGS describes a renal histologic lesion with diverse causes and pathogenicities that are
linked by podocyte injury and depletion. Subclasses of FSGS include primary, genetic, and …
linked by podocyte injury and depletion. Subclasses of FSGS include primary, genetic, and …
[HTML][HTML] An eQTL landscape of kidney tissue in human nephrotic syndrome
CE Gillies, R Putler, R Menon, E Otto… - The American Journal of …, 2018 - cell.com
Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression
and, in disease research, can be particularly illuminating when using the tissues directly …
and, in disease research, can be particularly illuminating when using the tissues directly …
Podocyte–actin dynamics in health and disease
Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …
that are involved in regulating the permselective properties of the glomerular filtration …
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models
Progressive kidney diseases are often associated with scarring of the kidney's filtration unit,
a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of …
a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of …
CureGN study rationale, design, and methods: establishing a large prospective observational study of glomerular disease
LH Mariani, AS Bomback, PA Canetta… - American journal of …, 2019 - Elsevier
Rationale & Objectives Glomerular diseases, including minimal change disease, focal
segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) …
segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) …
[HTML][HTML] A multi-layered quantitative in vivo expression atlas of the podocyte unravels kidney disease candidate genes
MM Rinschen, M Gödel, F Grahammer, S Zschiedrich… - Cell reports, 2018 - cell.com
Damage to and loss of glomerular podocytes has been identified as the culprit lesion in
progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with …
progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with …
[HTML][HTML] From podocyte biology to novel cures for glomerular disease
E Torban, F Braun, N Wanner, T Takano, PR Goodyer… - Kidney international, 2019 - Elsevier
The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is
central to the underlying pathophysiology of many common glomerular diseases, including …
central to the underlying pathophysiology of many common glomerular diseases, including …