Schizophrenia is a psychiatric disorder which has a lifetime prevalence of~ 1%. Multiple
candidate mechanisms have been proposed in the pathogenesis of schizophrenia. One …

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are
the end product of a cell lineage which has to undergo a complex and precisely timed …

Background Neuroinflammation and white matter pathology have each been independently
associated with schizophrenia, and experimental studies have revealed mechanisms by …

Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric
illness. While systemic autoimmune diseases are well-documented causes of …

The estimation of the number or density of neurons and types of glial cells and their relative
proportions in different brain areas are at the core of rigorous quantitative neuroanatomical …

Converging evidence from diverse studies suggests that atypical brain connectivity in autism
affects in distinct ways short-and long-range cortical pathways, disrupting neural …

Neural communication is disrupted in autism by unknown mechanisms. Here, we examined
whether in autism there are changes in axons, which are the conduit for neural …

Multiple lines of evidence in schizophrenia, from brain imaging, studies in postmortem
brains, and genetic association studies, have implicated oligodendrocyte and myelin …

Schizophrenia (SZ) is a neurodevelopmental disorder with a broad symptomatology,
including cognitive symptoms that are thought to arise from the prefrontal cortex (PFC). The …

Oligodendrocytes are cells that myelinate axons, providing saltatory conduction of action
potentials and proper function of the central nervous system. Myelination begins prenatally …