Metabolism of tissue macrophages in homeostasis and pathology
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …
anabolism to generate cellular energy and structural components. The emerging field of …
Myeloid cell-targeted therapies for solid tumours
Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …
where they have a variety of functions, ranging from immunosuppressive to …
Indoleamine 2, 3-dioxygenase (IDO) inhibitors and cancer immunotherapy
Strategies for unlocking immunosuppression in the tumor microenvironment have been
investigated to overcome resistance to first-generation immune checkpoint blockade with …
investigated to overcome resistance to first-generation immune checkpoint blockade with …
Gut microbiota-derived tryptophan metabolites maintain gut and systemic homeostasis
X Su, Y Gao, R Yang - Cells, 2022 - mdpi.com
Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into
different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such …
different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such …
Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis
J Wang, N Zhu, X Su, Y Gao, R Yang - Cells, 2023 - mdpi.com
The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …
Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
[HTML][HTML] Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies
S Koyama, H Nishikawa - Journal for immunotherapy of cancer, 2021 - ncbi.nlm.nih.gov
With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …
Control of tumor-associated macrophage responses by nutrient acquisition and metabolism
Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …
Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy
Inflammatory bowel disease (IBD), comprised of ulcerative colitis and Crohn's disease, is a
chronic relapsing inflammatory disease of the gastrointestinal tract that closely related to …
chronic relapsing inflammatory disease of the gastrointestinal tract that closely related to …
Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities
G Wang, K Zhong, Z Wang, Z Zhang, X Tang… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults.
Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and …
Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and …