Microsatellite instability (MSI) is a key biomarker in colorectal cancer (CRC), with crucial
diagnostic, prognostic, and predictive implications. Testing for mismatch repair deficiency …

Purpose Endometrial cancer (EC) is often the sentinel cancer in women with Lynch
syndrome (LS). However, efforts to implement universal LS screening in EC patients have …

Hereditary colorectal cancer (HCRC) accounts for< 5% of all colorectal cancer cases. Some
of the unique characteristics commonly encountered in HCRC cases include early age of …

Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …

Defective DNA mismatch repair (dMMR) is associated with many cancer types including
colon, gastric, endometrial, ovarian, hepatobiliary tract, urinary tract, brain and skin cancers …

Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …

Lynch syndrome is one of the most common hereditary cancer predisposition syndromes
and is associated with increased risks of colorectal and endometrial cancer, as well as …

Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal
cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene …

Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes,
are at increased risk of developing malignancies, in particular colorectal cancer (CRC) …

Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …