Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Discovery of metal-based complexes as promising antimicrobial agents

J Liang, D Sun, Y Yang, M Li, H Li, L Chen - European Journal of Medicinal …, 2021 - Elsevier
The antimicrobial resistance (AMR) is an intractable problem for the world. Metal ions are
essential for the cell process and biological function in microorganisms. Many metal-based …

Simultaneous Activation of Immunogenic Cell Death and cGAS-STING Pathway by Liver-and Mitochondria-Targeted Gold (I) Complexes for Chemoimmunotherapy of …

F Li, Z Wen, C Wu, Z Yang, Z Wang… - Journal of Medicinal …, 2024 - ACS Publications
Induction of immunogenic cell death (ICD) and activation of the cyclic GMP-AMP synthase
stimulator of interferon gene (cGAS-STING) pathway are two potent anticancer …

Biotin-Targeted Au (I) radiosensitizer for cancer synergistic therapy by intervening with redox homeostasis and inducing ferroptosis

Z Yang, S Huang, Y Liu, X Chang, Y Liang… - Journal of Medicinal …, 2022 - ACS Publications
The search for highly selective sensitizers with a novel mechanism for tumor targeting
therapy is of considerable interest. In this work, we have developed a series of new biotin …

PEPPSI type Pd (II) NHC complexes bearing chloro-/fluorobenzyl group: Synthesis, characterization, crystal structures, α-glycosidase and acetylcholinesterase …

S Bal, Ö Demirci, B Şen, P Taslimi, A Aktaş, Y Gök… - Polyhedron, 2021 - Elsevier
This work reported the synthesis of a new PEPPSI (Pyridine Enhanced Precatalyst
Preparation, Stabilization and Initiation) type Pd (II) N-heterocyclic carbene (NHC) …

Synthesis, characterization and bioactivities of dative donor ligand N-heterocyclic carbene (NHC) precursors and their Ag (I) NHC coordination compounds

A Kazancı, Y Gök, R Kaya, A Aktaş, P Taslimi, İ Gülçin - Polyhedron, 2021 - Elsevier
This study contains the synthesis of N-phthalimidomethyl-substituted NHC precursors and
their Ag (I) NHC coordination compounds. The NHC precursors were synthesized from the 1 …

Gold (III) derivatives in colon cancer treatment

A Gurba, P Taciak, M Sacharczuk… - International Journal of …, 2022 - mdpi.com
Cancer is one of the leading causes of morbidity and mortality worldwide. Colorectal cancer
(CRC) is the third most frequently diagnosed cancer in men and the second in women …

A focus on the biological targets for coinage metal-NHCs as potential anticancer complexes

F Guarra, A Pratesi, C Gabbiani, T Biver - Journal of Inorganic Biochemistry, 2021 - Elsevier
Metal complexes of N-heterocyclic carbene (NHC) ligands are the object of increasing
attention for therapeutic purposes. Among the different metal centres, interest on Au-based …

Novel Au carbene complexes as promising multi-target agents in breast cancer treatment

J Ceramella, A Mariconda, M Sirignano, D Iacopetta… - Pharmaceuticals, 2022 - mdpi.com
Over the past decade, metal complexes based on N-heterocyclic carbenes (NHCs) have
attracted great attention due to their wide and exciting applications in material sciences and …

gold (I) bis (1, 2, 3-triazol-5-ylidene) complexes as promising selective anticancer compounds

JF Schlagintweit, CHG Jakob, NL Wilke… - Journal of Medicinal …, 2021 - ACS Publications
The synthesis and antiproliferative activity of Mes-and iPr-substituted gold (I) bis (1, 2, 3-
triazol-5-ylidene) complexes in various cancer cell lines are reported, showing nanomolar …