Alopecia areata (AA) is believed to be a cell-mediated autoimmune hair loss disease. Both
CD4 and cytotoxic CD8 T cells (CTLs) are important for the onset and progression of AA …

Dendritic cell (DC)-based therapy has proved to be effective in patients with a variety of
malignancies. However, an optimal immunization protocol using DCs and the best means …

We performed a phase 1/2 trial testing the safety, toxicity, and immune response of a vaccine
consisting of autologous dendritic cells (DCs) transduced with a replication-defective …

Despite advances in animal studies, where the cure of the majority of mice with pre-
established (albeit early-stage) tumors has become almost standard, human clinical trials …

Background Cancer vaccines are designed to promote systemic antitumor immunity and
tumor eradication. Cancer vaccination may be more efficacious in combination with …

This study was to determine whether BMDCs cultured in the presence of IL-10 (G/10-DCs)
could promote T cell tolerance and prevent autoimmune diabetes in two different animal …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and is often
diagnosed at an advanced stage. We have investigated α-fetoprotein (AFP) as a tumor …

Dendritic cells (DC) present antigenic epitopes to and activate T cells. They also polarize the
ensuing T cell response to Th1 or Th2 type response, depending on their cytokine …

Gene-based modulation of immune functions is a promising means of eliciting protective
immunity and induction of tolerance. Novel viral and non-viral DNA delivery systems are …

Dendritic cell (DC) immunotherapy has shown a promising ability to promote anti-tumor
immunity in vitro and in vivo. Many trials have tested single epitopes and single antigens to …