Chromosomal rearrangements involving the NTRK1, NTRK2, and NTRK3 genes (NTRK
genes), which encode the high-affinity nerve growth factor receptor (TRKA), brain-derived …

Extracellular vesicles (EVs) occur in a variety of bodily fluids and have gained recent
attraction as natural materials due to their bioactive surfaces, internal cargo, and role in …

Major advances in the treatment of non-small cell lung cancer (NSCLC) patients have been
obtained during the last decade. Molecular testing of tumor samples is therefore mandatory …

Introduction The identification of tumour mutational burden (TMB) as a biomarker of
response to programmed cell death protein 1 (PD-1) immunotherapy has necessitated the …

Several kinase fusions are established targetable drivers in lung cancers. However, rapid
and comprehensive detection remains challenging because of diverse partner genes and …

Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype of non-
Hodgkin's lymphomas (NHL). DLBCL is an aggressive malignancy that displays a great …

Simple Summary Liquid biopsy, defined as the family of methods aimed at identifying tumor
biomarkers through noninvasive analysis of body fluids, is gaining more and more interest in …

Abstract Background Inflammatory myofibroblastic tumors (IMTs) are exceptionally rare
neoplasms, which are often driven by rearranged tyrosine kinases. Methods This study …

Recently, approval of tyrosine receptor kinase (TRK) inhibitors by Food and Drug
Administration and European Medicines Agency in NTRK fusion-positive cancer types has …

This review aims to provide an overview of the molecular pathogenesis thyroid carcinomas,
emphasizing genetic alterations that are therapeutically actionable. The main pathways in …