[HTML][HTML] Principles for targeting RNA with drug-like small molecules
KD Warner, CE Hajdin, KM Weeks - Nature reviews Drug discovery, 2018 - nature.com
RNA molecules are essential for cellular information transfer and gene regulation, and
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
Targeting mRNA processing as an anticancer strategy
J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
Functional carbon quantum dots as medical countermeasures to human coronavirus
A Łoczechin, K Séron, A Barras… - … applied materials & …, 2019 - ACS Publications
Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are
urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are …
urgently needed. Anticoronavirus therapy is however challenging, as coronaviruses are …
1, 2, 3‐Triazole hybrids with anti‐HIV‐1 activity
LS Feng, MJ Zheng, F Zhao, D Liu - Archiv der Pharmazie, 2021 - Wiley Online Library
The human immunodeficiency virus type 1 (HIV‐1) is the major etiological agent responsible
for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease …
for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease …
Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA
The interactions between cellular RNAs in MDA-MB-231 triple negative breast cancer cells
and a panel of small molecules appended with a diazirine cross-linking moiety and an …
and a panel of small molecules appended with a diazirine cross-linking moiety and an …
Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
The RNA pseudoknot that stimulates programmed ribosomal frameshifting in SARS-CoV-2
is a possible drug target. To understand how it responds to mechanical tension applied by …
is a possible drug target. To understand how it responds to mechanical tension applied by …
Small molecule–RNA targeting: starting with the fundamentals
AE Hargrove - Chemical Communications, 2020 - pubs.rsc.org
The structural and regulatory elements in therapeutically relevant RNAs offer many
opportunities for targeting by small molecules, yet fundamental understanding of what drives …
opportunities for targeting by small molecules, yet fundamental understanding of what drives …
Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents
The triazole ring system has emerged as an exciting prospect in the optimization studies of
promising lead molecules in the quest for new drugs for clinical usage. Several marketed …
promising lead molecules in the quest for new drugs for clinical usage. Several marketed …
Fragment-based approaches to identify RNA binders
Although fragment-based drug discovery (FBDD) has been successfully implemented and
well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the …
well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the …
Anti-frameshifting ligand active against SARS coronavirus-2 is resistant to natural mutations of the frameshift-stimulatory pseudoknot
Abstract SARS-CoV-2 uses− 1 programmed ribosomal frameshifting (− 1 PRF) to control
expression of key viral proteins. Because modulating− 1 PRF can attenuate the virus …
expression of key viral proteins. Because modulating− 1 PRF can attenuate the virus …