Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

Infectious diseases, which often result in deadly sepsis or septic shock, represent a major
global health problem. For understanding the pathophysiology of sepsis and developing …

Ethnopharmacological relevance Xuebijing injections originate from the traditional Chinese
medicine (TCM) prescription XuefuZhuyu Decoction. It is composed of five Chinese herbal …

Background Sepsis is a systemic inflammatory response syndrome caused by severe
infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory …

The pathophysiology of renal failure in septic shock is complex. Although microvascular
dysfunction has been proposed as a mechanism, there are controversial findings about the …

Simple Summary Microcirculation refers to the smallest blood vessels within the body.
During inflammation, changes can occur within these vessels which can further disease …

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. There are multiple cytokines involved in the process of sepsis. As an …

Systemic inflammation and hemodynamic or microvascular alterations are a hallmark of
sepsis and play a role in organs hypoperfusion and dysfunction. Pimobendan, an inodilator …

Background Septic shock is a life-threatening condition that can lead to organ dysfunction
and death. In the ICU, monitoring of cardiac index (CI) and heart rate (HR) is commonly used …

Sepsis-related circulatory failure with deficiency of tissue perfusion, is a life-threatening
clinical emergency. Microcirculatory alterations play a vital role in pathophysiologic …