The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …

Abstract Purpose of Review Since 2015, when ESC guidelines for the diagnosis and
management of pericardial diseases were published, ongoing research has enhanced the …

The COVID-19 pandemic is challenging our cardiovascular care of patients with heart
diseases. In the setting of pericardial diseases, there are two possible different scenarios to …

Abstract The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the
functioning of innate and adaptive immunity and the genesis of inflammation. They are …

The field of inflammatory disease of the heart or “cardio-immunology” is rapidly evolving due
to the wider use of non-invasive diagnostic tools able to detect and monitor myocardial …

Coronary atherosclerosis is a chronic pathological process that involves inflammation
together with endothelial dysfunction and lipoprotein dysregulation. Experimental studies …

Abstract Anti-interleukin (IL)-1 agents have been developed for the treatment of
autoinflammatory and rheumatic conditions, where overproduction of IL-1 is an important …

Background Idiopathic recurrent pericarditis (IRP) is a rare autoinflammatory disease.
Interleukin (IL)-1α and IL-1β are the pivotal cytokines in the pathophysiology of acute …

Pericardial diseases are an heterogeneous group of entities, ranging from acute pericarditis
to asymptomatic pericardial effusions. New advances in understanding the processes …