Abstract The Ah receptor (AhR) is a ligand-dependent transcription factor that mediates a
wide range of biological and toxicological effects that result from exposure to a structurally …

The hippocampus is an area of the brain that undergoes dramatic plasticity in response to
experience and hormone exposure. The hippocampus retains the ability to produce new …

HOXB13 is a member of the homeodomain family of sequence-specific transcription factors
and, together with the androgen receptor (AR), plays a critical role in the normal …

Peroxisome proliferator‐activated receptors (PPARs), members of the nuclear hormone
receptor superfamily, function as transcription factors and modulators of gene expression …

The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that lacks
estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 …

The present‐day concept of drug efficacy has changed completely from its original
description as the property of agonists that causes tissue activation. The ability to visualize …

Estrogen therapy and hormone therapy are effective options for the prevention and
treatment of osteoporosis, although because of their significant side effect profile, long term …

Although significant advances in the treatment of breast cancer have been made, in
particular in the use of endocrine therapy, de novo and aquired resistance to therapy, and …

Because of their central importance in gene regulation and mediating the actions of many
hormones, the nuclear receptors (NRs) have long been recognized as very important …