Homocysteine–from disease biomarker to disease prevention

AD Smith, H Refsum - Journal of internal medicine, 2021 - Wiley Online Library
We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Modulation of the inflammatory response in polycystic ovary syndrome (PCOS)—searching for epigenetic factors

D Szukiewicz, S Trojanowski, A Kociszewska… - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age. Despite its incidence, the syndrome is poorly understood and remains …

Personalized nutrition in the management of female infertility: new insights on chronic low-grade inflammation

G Fabozzi, G Verdone, M Allori, D Cimadomo… - Nutrients, 2022 - mdpi.com
Increasing evidence on the significance of nutrition in reproduction is emerging from both
animal and human studies, suggesting a mutual association between nutrition and female …

Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation

Q Shi, R Liu, L Chen - Molecular Medicine Reports, 2022 - spandidos-publications.com
Polycystic ovary syndrome is one of the most common endocrine and metabolic
gynecological disorders, of which dysfunction of ovarian granulosa cells is a key contributing …

Homocysteine is an indicator of arterial stiffness in Chinese women with polycystic ovary syndrome

X Wu, Z Li, W Sun, H Zheng - Endocrine connections, 2021 - ec.bioscientifica.com
Polycystic ovary syndrome (PCOS) is associated with an increased risk of cardiovascular
disease in women. Hyperhomocysteinemia (H-Hcy) is closely related to arterial stiffness …

Effects of MTHFR C677T polymorphism on homocysteine and vitamin D in women with polycystic ovary syndrome

J Zhao, X Li, Q Chen - Gene, 2024 - Elsevier
Objectives To evaluate the correlation between serum vitamin D, homocysteine and the
methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism in women with …

Homocysteine, vitamin B12, and folate circulating levels in women with and without polycystic ovary syndrome: A systematic review and meta-analysis

JR Ulloque-Badaracco… - Women's …, 2024 - journals.sagepub.com
Background: Some studies have reported that homocysteine, vitamin B12, and folic acid
levels are associated with polycystic ovary syndrome (PCOS), whereas other studies yielded …

Causal Relationships between Homocysteine and the Polycystic Ovary Syndrome: A Mendelian Randomization Analysis

X Lin, Y Jin, S Hong - International Journal of Endocrinology, 2024 - Wiley Online Library
Background. Polycystic ovary syndrome (PCOS) is an endocrine disease attributed to
multiple genetic variants and environmental factors. We aimed to find the causal association …

Vitamin B12 is correlated with insulin resistance and metabolism disorder markers in women with recurrent pregnancy loss

X Deng, D Qin, Q Ding, L Peng, G Li, S Bao - Journal of Gynecology …, 2025 - Elsevier
Objectives Recurrent pregnancy loss (RPL) seriously affects women's reproductive and
mental health, and the incidence has increased in recent years. Insulin resistance (IR) acts …

Utero-placental (vascular) development throughout pregnancy in women with polycystic ovary syndrome: the Rotterdam Periconceptional Cohort

LL Berns, RE Wiegel, AHJ Koning, SP Willemsen… - F&S Reports, 2024 - Elsevier
Objective To study utero-placental vascular development from the first trimester onwards in
pregnant women with PCOS with successful live births, compared to pregnant women …