The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

General anaesthetics are much more selective than is usually appreciated and may act by
binding to only a small number of targets in the central nervous system. At surgical …

There was a time when cultured Eng-lishmen would embark on a Grand Tour of Europe,
visiting important cities and inspecting monuments and vistas. The book of Penrose is a …

“Suffering so great as I underwent cannot be expressed in words... but the blank whirlwind of
emotion, the horror of great darkness, and the sense of desertion by God and man, which …

Although general anaesthesia has been of tremendous importance for the development of
surgery, the underlying mechanisms by which this state is achieved are only just beginning …

Potential features of quantum computation could explain enigmatic aspects of
consciousness. The Penrose—Hameroff model (orchestrated objective reduction:'Orch OR') …

The motivation for this review arises from the conviction that, as a result of the mass of
experimental data and observations collected in recent years, the study of the physical …

In this review first we evaluate evidence on the role of the neurobiological alterations
induced by chronic ethanol consumption in the development of ethanol tolerance …

The paper begins with a general introduction to the nature of human consciousness and
outlines several different philosophical approaches. A critique of traditional reductionist and …

Most proteins are insensitive to the presence of anaesthetics at concentrations which induce
general anaesthesia, while some are inhibited by certain agents but not others1. Here we …