What is the pipeline for future medications for obesity?
E Melson, U Ashraf, D Papamargaritis… - International Journal of …, 2024 - nature.com
Obesity is a chronic disease associated with increased risk of obesity-related complications
and mortality. Our better understanding of the weight regulation mechanisms and the role of …
and mortality. Our better understanding of the weight regulation mechanisms and the role of …
[HTML][HTML] Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?
S Kloock, CG Ziegler, U Dischinger - Pharmacology & Therapeutics, 2023 - Elsevier
Obesity and its comorbidities, including type 2 diabetes mellitus, cardiovascular disease,
heart failure and non-alcoholic liver disease are a major health and economic burden with …
heart failure and non-alcoholic liver disease are a major health and economic burden with …
GDF15 linked to maternal risk of nausea and vomiting during pregnancy
M Fejzo, N Rocha, I Cimino, SM Lockhart, CJ Petry… - Nature, 2024 - nature.com
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting
of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full …
of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full …
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
KA Sjøberg, CM Sigvardsen, A Alvarado-Diaz… - Cell metabolism, 2023 - cell.com
Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …
action in obese rodents. Whether and how GDF15 improves insulin action without weight …
GDF15 is a major determinant of ketogenic diet-induced weight loss
JF Lu, MQ Zhu, B Xia, NN Zhang, XP Liu, H Liu… - Cell Metabolism, 2023 - cell.com
A ketogenic diet (KD) has been promoted as an obesity management diet, yet its underlying
mechanism remains elusive. Here we show that KD reduces energy intake and body weight …
mechanism remains elusive. Here we show that KD reduces energy intake and body weight …
Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH
L L'homme, BP Sermikli, JT Haas, S Fleury… - Nature …, 2024 - nature.com
Plasma growth differentiation factor-15 (GDF-15) levels increase with obesity and metabolic
dysfunction-associated steatotic liver disease (MASLD) but the underlying mechanism …
dysfunction-associated steatotic liver disease (MASLD) but the underlying mechanism …
Evolving Approaches for Pharmacological Therapy of Obesity
AM Chao, S Taylor, M Moore, A Amaro… - Annual Review of …, 2025 - annualreviews.org
Obesity is a global health concern. Progress in understanding the physiology of obesity and
weight reduction has provided new drug targets. Development and testing of new …
weight reduction has provided new drug targets. Development and testing of new …
The roles of FGF21 and GDF15 in mediating the mitochondrial integrated stress response
J Jena, LM García-Peña, RO Pereira - Frontiers in Endocrinology, 2023 - frontiersin.org
Various models of mitochondrial stress result in induction of the stress-responsive cytokines
fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15). This is an …
fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15). This is an …
Obesity and the kidney: mechanistic links and therapeutic advances
Obesity is strongly associated with the development of diabetes mellitus and chronic kidney
disease (CKD), but there is evidence for a bidirectional relationship wherein the kidney also …
disease (CKD), but there is evidence for a bidirectional relationship wherein the kidney also …