How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …

Topologically associating domains (TADs) are fundamental structural and functional
building blocks of human interphase chromosomes, yet the mechanisms of TAD formation …

Abstract Capture Hi-C (CHi-C) is a method for profiling chromosomal interactions involving
targeted regions of interest, such as gene promoters, globally and at high resolution. Signal …

Genomes of eukaryotes are partitioned into domains of functionally distinct chromatin states.
These domains are stably inherited across many cell generations and can be remodeled in …

Chromatin has a complex spatial organization in the cell nucleus that serves vital functional
purposes. A variety of chromatin folding conformations has been detected by single-cell …

Loop-extrusion and phase-separation have been proposed as mechanisms that shape
chromosome spatial organization. It is unclear, however, how they perform relative to each …

The spatial organization of chromosomes has key functional roles, yet how chromosomes
fold remains poorly understood at the single-molecule level. Here, we employ models of …

Structural variants (SVs) can result in changes in gene expression due to abnormal
chromatin folding and cause disease. However, the prediction of such effects remains a …

Chromatin is organized in a highly ordered yet dynamic manner in the cell nucleus, but the
principles governing this organization remain unclear. Similarly, it is unknown whether, and …