Angiogenesis and disruption of liver vascular architecture have been linked to progression
to cirrhosis and liver cancer (HCC) in chronic liver diseases, which contributes both to …

Cancer therapy has progressed remarkably in recent years. In no area has this been more
apparent than in the development of'targeted therapies', particularly those using drugs that …

Targeted therapeutics, particularly those that inhibit the activity of protein kinases that are
mutated and/or overexpressed in cancer, have revolutionized the treatment of some cancers …

transduction of both extracellular and intracellular signals. Because of their critical role in
normal cellular communication and maintenance of homeostasis, tyrosine kinase activity is …

The higher patency rates of cardiovascular implants, including vascular bypass grafts,
stents, and heart valves are related to their ability to inhibit thrombosis, intimal hyperplasia …

Bone marrow mesenchymal stem cells (MSCs) participate in myocardial repair following
myocardial infarction. However, their in vivo reparative capability is limited due to lack of …

Background—Oxidative stress, generated by excessive reactive oxygen species, promotes
cardiovascular disease. Cyclophilin A (CyPA) is a 20-kDa chaperone protein secreted from …

In 2002, Hoshijima and Chien drew largely theoretical parallels between the dysregulation
of the signaling pathways driving cancer and those driving cardiac hypertrophy (Hoshijima …

Upon secretion, transforming growth factor β (TGFβ) is maintained in a sequestered state in
extracellular matrix as a latent form. The latent TGFβ is considered as a molecular sensor …

Background c-Kit is a receptor tyrosine kinase present in multiple cell types, including
vascular smooth muscle cells (SMC). However, little is known about how c-Kit influences …