Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …

The MCM motor of the replicative helicase is loaded onto origin DNA as an inactive double
hexamer before replication initiation. Recruitment of activators GINS and Cdc45 upon S …

Accurate processing of stalled or damaged DNA replication forks is paramount to genomic
integrity and recent work points to replication fork reversal and restart as a central …

Faithful cell division is the basis for the propagation of life and DNA replication must be
precisely regulated. DNA replication stress is a prominent endogenous source of genome …

Topoisomerase I (TOP1) inhibitors are an important class of anticancer drugs. The
cytotoxicity of TOP1 inhibitors can be modulated by replication fork reversal through a …

The concept that G-quadruplex (G4) structures can form within DNA or RNA in vitro has
been long known and extensively discussed. In recent years, accumulating evidences imply …

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Several monogenic inherited diseases that display features of human …

The RecQ family of DNA helicases is highly conserved throughout evolution, and is
important for the maintenance of genome stability. In humans, five RecQ family members …

The transmission and maintenance of genetic information in eukaryotic cells relies on the
faithful duplication of the entire genome. In each round of division, excessive replication …