Natural products targeting strategies involving molecular networking: different manners, one goal

AEF Ramos, L Evanno, E Poupon, P Champy… - Natural product …, 2019 - pubs.rsc.org
Covering: up to 2019 Landmark advances in bioinformatics tools have recently enhanced
the field of natural products research, putting today's natural product chemists in the …

Innovative omics-based approaches for prioritisation and targeted isolation of natural products–new strategies for drug discovery

JL Wolfender, M Litaudon, D Touboul… - Natural product …, 2019 - pubs.rsc.org
Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …

Advancements in capturing and mining mass spectrometry data are transforming natural products research

SA Jarmusch, JJJ van der Hooft, PC Dorrestein… - Natural product …, 2021 - pubs.rsc.org
Covering: 2016 up to 2021 Mass spectrometry (MS) is an essential technology in natural
products research with MS fragmentation (MS/MS) approaches becoming a key tool. Recent …

Feature-Based Molecular Networking Discovery of Bromopyrrole Alkaloids from the Marine Sponge Agelas dispar

VF Freire, JR Gubiani, TM Spencer… - Journal of natural …, 2022 - ACS Publications
Investigation of the marine sponge Agelas dispar MeOH fractions using feature-based
molecular networking, dereplication, and isolation led to the discovery of new bromopyrrole …

Combination of untargeted metabolomics approach and molecular networking analysis to identify unique natural components in wild Morchella sp. by UPLC-Q-TOF …

X Zhao, E Hengchao, H Dong, Y Zhang, J Qiu, Y Qian… - Food Chemistry, 2022 - Elsevier
Morchella sp. is a typical edible fungus. However, its unique natural products, especially
bioactive composition, are rarely reported. In this study, an untargeted metabolomics …

Rapid discovery of two unprecedented meroterpenoids from Daphne altaica Pall. using molecular networking integrated with MolNetEnhancer and Network …

WY Zhou, ZH Xi, NN Du, L Ye, MH Jiang, JL Hao… - Chinese Chemical …, 2024 - Elsevier
Under the guidance of the approach which integrates molecular networking,
MolNetEnhancer and Network Annotation Propagation (NAP), daphnaltaicanoids A and B (1 …

Integrating Molecular Networking and 1H NMR To Target the Isolation of Chrysogeamides from a Library of Marine-Derived Penicillium Fungi

XM Hou, YY Li, YW Shi, YW Fang, R Chao… - The Journal of …, 2019 - ACS Publications
A challenging problem in natural product discovery is to rapidly dereplicate known
compounds and expose novel ones from complicated components. Herein, integrating the …

UPLC-MS/MS-based molecular networking and NMR structural determination for the untargeted phytochemical characterization of the fruit of Crescentia cujete …

A Rivera-Mondragón, E Tuenter, O Ortiz, ME Sakavitsi… - Phytochemistry, 2020 - Elsevier
The fruit pulp of Crescentia cujete is traditionally used in folk medicine for the treatment of a
variety of respiratory conditions and gastrointestinal disorders. Due to the lack of a …

Molecular Networking Reveals the Chemical Diversity of Selaginellin Derivatives, Natural Phosphodiesterase-4 Inhibitors from Selaginella tamariscina

S Woo, KB Kang, J Kim, SH Sung - Journal of natural products, 2019 - ACS Publications
Selaginellins are unique pigments found in the genus Selaginella, the largest genus of
Lycopodiophyta. Recent studies reported that some selaginellin analogues have potent …

Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus

MM Zdouc, M Iorio, SI Maffioli… - Journal of Natural …, 2021 - ACS Publications
Despite an excellent track record, microbial drug discovery suffers from high rates of
rediscovery. Better workflows for the rapid investigation of complex extracts are needed to …