Natural products targeting strategies involving molecular networking: different manners, one goal
Covering: up to 2019 Landmark advances in bioinformatics tools have recently enhanced
the field of natural products research, putting today's natural product chemists in the …
the field of natural products research, putting today's natural product chemists in the …
Innovative omics-based approaches for prioritisation and targeted isolation of natural products–new strategies for drug discovery
Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …
biological sources has led to major drug discoveries. Over the past two decades, despite the …
Advancements in capturing and mining mass spectrometry data are transforming natural products research
Covering: 2016 up to 2021 Mass spectrometry (MS) is an essential technology in natural
products research with MS fragmentation (MS/MS) approaches becoming a key tool. Recent …
products research with MS fragmentation (MS/MS) approaches becoming a key tool. Recent …
Feature-Based Molecular Networking Discovery of Bromopyrrole Alkaloids from the Marine Sponge Agelas dispar
VF Freire, JR Gubiani, TM Spencer… - Journal of natural …, 2022 - ACS Publications
Investigation of the marine sponge Agelas dispar MeOH fractions using feature-based
molecular networking, dereplication, and isolation led to the discovery of new bromopyrrole …
molecular networking, dereplication, and isolation led to the discovery of new bromopyrrole …
Combination of untargeted metabolomics approach and molecular networking analysis to identify unique natural components in wild Morchella sp. by UPLC-Q-TOF …
X Zhao, E Hengchao, H Dong, Y Zhang, J Qiu, Y Qian… - Food Chemistry, 2022 - Elsevier
Morchella sp. is a typical edible fungus. However, its unique natural products, especially
bioactive composition, are rarely reported. In this study, an untargeted metabolomics …
bioactive composition, are rarely reported. In this study, an untargeted metabolomics …
Rapid discovery of two unprecedented meroterpenoids from Daphne altaica Pall. using molecular networking integrated with MolNetEnhancer and Network …
WY Zhou, ZH Xi, NN Du, L Ye, MH Jiang, JL Hao… - Chinese Chemical …, 2024 - Elsevier
Under the guidance of the approach which integrates molecular networking,
MolNetEnhancer and Network Annotation Propagation (NAP), daphnaltaicanoids A and B (1 …
MolNetEnhancer and Network Annotation Propagation (NAP), daphnaltaicanoids A and B (1 …
Integrating Molecular Networking and 1H NMR To Target the Isolation of Chrysogeamides from a Library of Marine-Derived Penicillium Fungi
XM Hou, YY Li, YW Shi, YW Fang, R Chao… - The Journal of …, 2019 - ACS Publications
A challenging problem in natural product discovery is to rapidly dereplicate known
compounds and expose novel ones from complicated components. Herein, integrating the …
compounds and expose novel ones from complicated components. Herein, integrating the …
UPLC-MS/MS-based molecular networking and NMR structural determination for the untargeted phytochemical characterization of the fruit of Crescentia cujete …
The fruit pulp of Crescentia cujete is traditionally used in folk medicine for the treatment of a
variety of respiratory conditions and gastrointestinal disorders. Due to the lack of a …
variety of respiratory conditions and gastrointestinal disorders. Due to the lack of a …
Molecular Networking Reveals the Chemical Diversity of Selaginellin Derivatives, Natural Phosphodiesterase-4 Inhibitors from Selaginella tamariscina
Selaginellins are unique pigments found in the genus Selaginella, the largest genus of
Lycopodiophyta. Recent studies reported that some selaginellin analogues have potent …
Lycopodiophyta. Recent studies reported that some selaginellin analogues have potent …
Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus
Despite an excellent track record, microbial drug discovery suffers from high rates of
rediscovery. Better workflows for the rapid investigation of complex extracts are needed to …
rediscovery. Better workflows for the rapid investigation of complex extracts are needed to …