With a sharp increase in the cases of multi-drug resistant (MDR) bacteria all over the world,
there is a huge demand to develop a new generation of antibiotic agents to fight them. As an …

Bioluminescence imaging (BLI) is a powerful method for visualizing biological processes
and tracking cells. Engineered bioluminescent bacteria that utilize luciferase-catalyzed …

Yersinia pestis causes human plague and colonizes both a mammalian host and a flea
vector during its transmission cycle. A key barrier to bacterial infection is the host's ability to …

Subverting the host immune response to inhibit inflammation is a key virulence strategy of
Yersinia pestis. The inflammatory cascade is tightly controlled via the sequential action of …

Nutritional immunity includes sequestration of transition metals from invading pathogens.
Yersinia pestis overcomes nutritional immunity by secreting yersiniabactin to acquire iron …

While preclinical and clinical imaging have been applied to drug discovery/development
and characterization of disease pathology, few examples exist where imaging has been …

A number of bacterial pathogens require the ZnuABC Zinc (Zn2+) transporter and/or a
second Zn2+ transport system to overcome Zn2+ sequestration by mammalian hosts …

The study of intracellular bacterial pathogens in cell culture hinges on inhibiting extracellular
growth of the bacteria in cell culture media. Aminoglycosides, like gentamicin, were …

Yersinia pestis can be transmitted by fleas during the first week after an infectious blood
meal, termed early-phase or mass transmission, and again after Y. pestis forms a cohesive …

Yersinia pestis has evolved many strategies to evade the innate immune system. One of
these strategies is the ability to survive within macrophages. Upon phagocytosis, Y. ápestis …