One of the most common drivers in human cancer is the mutant KRAS protein. Not so long
ago KRAS was considered as an undruggable oncoprotein. After a long struggle, however …

The Kirsten rat sarcoma viral (KRAS) oncogene is the most frequently mutated isoform of
RAS, associated with 85% of RAS-driven cancers. KRAS functions as a signaling hub …

Mutations yield significant effect on the structural flexibility of two switch domains, SW1 and
SW2, in K-Ras, which is considered as an important target of anticancer drug design. To …

Binding of partners and mutations highly affects the conformational dynamics of KRAS4B,
which is of significance for deeply understanding its function. Gaussian accelerated …

Mutations in K-Ras are involved in a large number of all human cancers, thus, K-Ras is
regarded as a promising target for anticancer drug design. Understanding the target roles of …

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …

This study employs a comprehensive approach combining protein retrieval, sequence
alignment, and molecular dynamics simulations to investigate the structural dynamics and …

Understanding the molecular mechanism of the GTP-KRAS binding is significant for
improving the target roles of KRAS in cancer treatment. In this work, multiple replica …

KRAS gene mutation is widespread in tumors and plays an important role in various
malignancies. Targeting KRAS mutations is regarded as the “holy grail” of targeted cancer …

A vast effort has been invested in the identification of driver mutations of cancer. However,
recent studies and observations call into question whether the activating mutations or the …