Dual targeting of the cancer antioxidant network with 1, 4-naphthoquinone fused gold (i) N-heterocyclic carbene complexes

R McCall, M Miles, P Lascuna, B Burney, Z Patel… - Chemical …, 2017 - pubs.rsc.org
To achieve a systems-based approach to targeting the antioxidant pathway, 1, 4-
naphthoquinone annulated N-heterocyclic carbene (NHC)[bis (1, 3-dimesityl-4, 5 …

Palladium-catalyzed external-oxidant-free coupling reactions between isoquinoline/quinoline N-oxides with olefins

T Guo, Y Liu, YH Zhao, PK Zhang, SL Han, HM Liu - Tetrahedron Letters, 2016 - Elsevier
A convenient and efficient approach for the synthesis of 1-alkenylisoquinolines and 2-
alkenylquinolines was developed via palladium-catalyzed coupling reactions between …

Evaluation of ortho-substituted Bis-Functionalized Triazoles as Tyrosinase Inhibitors: Modulating Dopamine Synthesis and Behavior in Zebrafish

S Landge, J Philp, A Ugboya, I Graves, E Fasusi… - Medicinal Chemistry …, 2024 - Springer
Facile and green chemistry pathways are utilized through microwave-assisted organic
synthesis (MAOS) to generate biologically active ortho-substituted bis-functionalized triazole …

C–H γ, γ, γ-Trifluoroalkylation of Quinolines via Visible-Light-Induced Sequential Radical Additions

Y Kumagai, N Murakami, F Kamiyama, R Tanaka… - Organic …, 2019 - ACS Publications
The photocatalyst-free C–H γ, γ, γ-trifluoroalkylation of quinolines under visible light
irradiation is reported. By the combination of readily available alkenes and Umemoto's …

Highly Chemoselective Synthesis of Azaarene-Equipped CF3-Tertiary Alcohols under Metal-Free Conditions and Their Fungicidal Activities

B Zhou, G Yang, C Wang, L Liu, L Shi, Z Pan, X Ji… - ACS …, 2022 - ACS Publications
A highly chemoselective reaction between α, β-unsaturated trifluoromethyl ketones with
azaarenes under metal-free conditions was carried out, affording a range of valuable …

Synthesis of novel rapanone derivatives via organocatalytic reductive C-alkylation: biological evaluation of antioxidant properties, in vivo zebrafish embryo toxicity …

V Mariyappan, G Munuswamy-Ramanujam… - RSC Medicinal …, 2024 - pubs.rsc.org
A biologically crucial natural product rapanone 1 was isolated from Embelia ribes at the
gram scale with excellent purity. Semi-synthetic analogs of 1 semi-synthesized through …

Ligand‐Free and Reusable Palladium Nanoparticles‐Catalyzed Alkylation of 2‐Alkylazaarenes with Activated Ketones under Neutral Conditions

N Parveen, A Muthukumar… - Advanced Synthesis & …, 2019 - Wiley Online Library
A mild, efficient, and stable binaphthyl‐stabilized palladium nanoparticles (Pd− BNP)
catalyzed (sp3) C− H reaction of 2‐alkylazaarenes with activated carbonyl compounds was …

Anti-Tumor Active Isopropylated Fused Azaisocytosine-Containing Congeners Are Safe for Developing Danio rerio as Well as Red Blood Cells and Activate Apoptotic …

M Sztanke, J Rzymowska, K Sztanke - Molecules, 2022 - mdpi.com
New isopropylated fused azaisocytosine-containing congeners (I–VI) have previously been
reported as promising anticancer drug candidates, so further research on these molecules in …

Anticancer active trifluoromethylated fused triazinones are safe for early-life stages of zebrafish (Danio rerio) and reveal a proapoptotic action

M Sztanke, J Rzymowska, K Sztanke - Journal of Enzyme Inhibition …, 2021 - Taylor & Francis
The main purpose of this investigation was to evaluate the effect of anticancer active
compounds (I–VIII) on zebrafish development in order to select the safest molecules. Larval …

Discovery of Quinoline‐Derived Trifluoromethyl Alcohols as Antiepileptic and Analgesic Agents That Block Sodium Channels

A Williams, L Villamor, J Fussell, R Loveless… - …, 2022 - Wiley Online Library
The discovery of novel analgesic agents with high potency, low toxicity and low addictive
properties remain a priority. This study aims to identify the analgesic potential of quinoline …