Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches

P Düsing, A Zietzer, PR Goody, MR Hosen… - Journal of molecular …, 2021 - Springer
Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney
disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor …

Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications

YX Xu, SD Pu, X Li, ZW Yu, YT Zhang, XW Tong… - Pharmacological …, 2022 - Elsevier
Exosomes are discoid vesicles with a diameter of 40–160 nm. They are mainly derived from
the multivesicular body formed by the invagination of lysosomal particles in the cell, which …

Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management

L Peng, Y Chen, S Shi, H Wen - Stem Cell Research & Therapy, 2022 - Springer
Background Despite major advances in the treatment of diabetic nephropathy (DN) in recent
years, it remains the most common cause of end-stage renal disease. An early diagnosis …

[HTML][HTML] Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications

J Liu, Y Zhang, Y Tian, W Huang, N Tong, X Fu - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …

[HTML][HTML] Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics

Z Payandeh, B Tangruksa, J Synnergren… - Molecular Aspects of …, 2024 - Elsevier
Modern methods of molecular diagnostics and therapy have revolutionized the field of
medicine in recent years by providing more precise and effective tools for detecting and …

Novel biomarkers of diabetic kidney disease: current status and potential clinical application

F Barutta, S Bellini, S Canepa, M Durazzo, G Gruden - Acta diabetologica, 2021 - Springer
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD).
Although both albuminuria and glomerular filtration rate (GFR) are well-established …

Serum exosomes from diabetic kidney disease patients promote pyroptosis and oxidative stress through the miR-4449/HIC1 pathway

C Gao, B Wang, Q Chen, M Wang, X Fei, N Zhao - Nutrition & Diabetes, 2021 - nature.com
Background Diabetic kidney disease (DKD) is a major contributor to end-stage renal
disease. Several microRNAs (miRNAs) have been found to be enriched in exosomes of …

Non-coding RNAs as biomarkers and therapeutic targets for diabetic kidney disease

YY Gu, FH Lu, XR Huang, L Zhang, W Mao… - Frontiers in …, 2021 - frontiersin.org
Diabetic kidney disease (DKD) is the most common diabetic complication and is a leading
cause of end-stage kidney disease. Increasing evidence shows that DKD is regulated not …

Interactions among non-coding RNAs in diabetic nephropathy

TS Loganathan, SA Sulaiman… - Frontiers in …, 2020 - frontiersin.org
Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD).
Although various treatments and diagnosis applications are available, DN remains a clinical …

Noncoding RNAs in diabetic nephropathy: pathogenesis, biomarkers, and therapy

J Lv, Y Wu, Y Mai, S Bu - Journal of diabetes research, 2020 - Wiley Online Library
The correlation between diabetes and systematic well‐being on human life has long
established. As a common complication of diabetes, the prevalence of diabetic nephropathy …