An overview of the bacterial carbonic anhydrases
CT Supuran, C Capasso - Metabolites, 2017 - mdpi.com
Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …
Antibacterial carbonic anhydrase inhibitors: an update on the recent literature
CT Supuran, C Capasso - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …
Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori
Our understanding of the function of bacterial carbonic anhydrases (CAs, EC 4.2. 1.1) has
increased significantly in the last years. CAs are metalloenzymes able to modulate CO2 …
increased significantly in the last years. CAs are metalloenzymes able to modulate CO2 …
Biomedical applications of prokaryotic carbonic anhydrases
CT Supuran, C Capasso - Expert Opinion on Therapeutic Patents, 2018 - Taylor & Francis
Introduction: The hydration/dehydration of CO2 catalyzed by carbonic anhydrases (CAs, EC
4.2. 1.1) is a crucial physiological reaction for the survival of all living organisms because it …
4.2. 1.1) is a crucial physiological reaction for the survival of all living organisms because it …
A highlight on the inhibition of fungal carbonic anhydrases as drug targets for the antifungal armamentarium
CT Supuran, C Capasso - International Journal of Molecular Sciences, 2021 - mdpi.com
Carbon dioxide (CO2), a vital molecule of the carbon cycle, is a critical component in living
organisms' metabolism, performing functions that lead to the building of compounds …
organisms' metabolism, performing functions that lead to the building of compounds …
Microbiota, bacterial carbonic anhydrases, and modulators of their activity: links to human diseases?
The involvement of the human microbiome is crucial for different host functions such as
protection, metabolism, reproduction, and especially immunity. However, both endogenous …
protection, metabolism, reproduction, and especially immunity. However, both endogenous …
Discovery of novel 1, 3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors
Abstract A series of new 1, 3-diaryltriazene sulfonamides was synthesised by reaction of
diazonium salt of metanilamide (3-aminobenzene sulfonamide) with substituted aromatic …
diazonium salt of metanilamide (3-aminobenzene sulfonamide) with substituted aromatic …
Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi
AB Vermelho, V da Silva Cardoso… - Journal of enzyme …, 2018 - Taylor & Francis
Sulfonamide carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors targeting the α-class enzyme
from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were …
from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were …
Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo [d] thiazole-5-and 6-sulfonamides
A series of benzo [d] thiazole-5-and 6-sulfonamides has been synthesized and investigated
for the inhibition of several human (h) carbonic anhydrase (CA, EC 4.2. 1.1) isoforms, using …
for the inhibition of several human (h) carbonic anhydrase (CA, EC 4.2. 1.1) isoforms, using …
Antifungal promising agents of zinc (II) and copper (II) derivatives based on azole drug
JA de Azevedo-França, LP Borba-Santos… - Journal of Inorganic …, 2021 - Elsevier
A series of new metal complexes,[Zn (KTZ) 2 (Ac) 2]· H 2 O (1),[Zn (KTZ) 2 Cl 2]· 0.4 CH 3 OH
(2),[Zn (KTZ) 2 (H 2 O)(NO 3)](NO 3)(3),[Cu (KTZ) 2 (Ac) 2]· H 2 O (4),[Cu (KTZ) 2 Cl 2]· 3.2 H …
(2),[Zn (KTZ) 2 (H 2 O)(NO 3)](NO 3)(3),[Cu (KTZ) 2 (Ac) 2]· H 2 O (4),[Cu (KTZ) 2 Cl 2]· 3.2 H …