An overview of the bacterial carbonic anhydrases

CT Supuran, C Capasso - Metabolites, 2017 - mdpi.com
Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …

Antibacterial carbonic anhydrase inhibitors: an update on the recent literature

CT Supuran, C Capasso - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …

Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori

C Campestre, V De Luca, S Carradori… - Frontiers in …, 2021 - frontiersin.org
Our understanding of the function of bacterial carbonic anhydrases (CAs, EC 4.2. 1.1) has
increased significantly in the last years. CAs are metalloenzymes able to modulate CO2 …

Biomedical applications of prokaryotic carbonic anhydrases

CT Supuran, C Capasso - Expert Opinion on Therapeutic Patents, 2018 - Taylor & Francis
Introduction: The hydration/dehydration of CO2 catalyzed by carbonic anhydrases (CAs, EC
4.2. 1.1) is a crucial physiological reaction for the survival of all living organisms because it …

A highlight on the inhibition of fungal carbonic anhydrases as drug targets for the antifungal armamentarium

CT Supuran, C Capasso - International Journal of Molecular Sciences, 2021 - mdpi.com
Carbon dioxide (CO2), a vital molecule of the carbon cycle, is a critical component in living
organisms' metabolism, performing functions that lead to the building of compounds …

Microbiota, bacterial carbonic anhydrases, and modulators of their activity: links to human diseases?

A Amedei, C Capasso, G Nannini… - Mediators of …, 2021 - Wiley Online Library
The involvement of the human microbiome is crucial for different host functions such as
protection, metabolism, reproduction, and especially immunity. However, both endogenous …

Discovery of novel 1, 3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors

S Akocak, N Lolak, S Bua… - Journal of Enzyme …, 2018 - Taylor & Francis
Abstract A series of new 1, 3-diaryltriazene sulfonamides was synthesised by reaction of
diazonium salt of metanilamide (3-aminobenzene sulfonamide) with substituted aromatic …

Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi

AB Vermelho, V da Silva Cardoso… - Journal of enzyme …, 2018 - Taylor & Francis
Sulfonamide carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors targeting the α-class enzyme
from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were …

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo [d] thiazole-5-and 6-sulfonamides

M Abdoli, A Angeli, M Bozdag, F Carta… - Journal of Enzyme …, 2017 - Taylor & Francis
A series of benzo [d] thiazole-5-and 6-sulfonamides has been synthesized and investigated
for the inhibition of several human (h) carbonic anhydrase (CA, EC 4.2. 1.1) isoforms, using …

Antifungal promising agents of zinc (II) and copper (II) derivatives based on azole drug

JA de Azevedo-França, LP Borba-Santos… - Journal of Inorganic …, 2021 - Elsevier
A series of new metal complexes,[Zn (KTZ) 2 (Ac) 2]· H 2 O (1),[Zn (KTZ) 2 Cl 2]· 0.4 CH 3 OH
(2),[Zn (KTZ) 2 (H 2 O)(NO 3)](NO 3)(3),[Cu (KTZ) 2 (Ac) 2]· H 2 O (4),[Cu (KTZ) 2 Cl 2]· 3.2 H …