Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm

J Bethony, S Brooker, M Albonico, SM Geiger… - The lancet, 2006 - thelancet.com
The three main soil-transmitted helminth infections, ascariasis, trichuriasis, and hookworm,
are common clinical disorders in man. The gastrointestinal tract of a child living in poverty in …

Helminth immunomodulation in autoimmune disease

TB Smallwood, PR Giacomin, A Loukas… - Frontiers in …, 2017 - frontiersin.org
Helminths have evolved to become experts at subverting immune surveillance. Through
potent and persistent immune tempering, helminths can remain undetected in human …

[HTML][HTML] Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity

JP Hewitson, JR Grainger, RM Maizels - Molecular and biochemical …, 2009 - Elsevier
Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a
Th2-dominated immune response, but stimulation of immunoregulatory cell populations …

Immunomodulation by helminth parasites: defining mechanisms and mediators

HJ McSorley, JP Hewitson, RM Maizels - International journal for …, 2013 - Elsevier
Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus

EM Schwarz, PK Korhonen, BE Campbell, ND Young… - Genome biology, 2013 - Springer
Background The barber's pole worm, Haemonchus contortus, is one of the most
economically important parasites of small ruminants worldwide. Although this parasite can …

A novel nematode effector suppresses plant immunity by activating host reactive oxygen species‐scavenging system

B Lin, K Zhuo, S Chen, L Hu, L Sun, X Wang… - New …, 2016 - Wiley Online Library
Evidence is emerging that plant‐parasitic nematodes can secrete effectors to interfere with
the host immune response, but it remains unknown how these effectors can conquer host …

[PDF][PDF] Molecules released by helminth parasites involved in host colonization

J Dzik - Acta Biochimica Polonica, 2006 - bibliotekanauki.pl
Parasites are designed by evolution to invade the host and survive in its organism until they
are ready to reproduce. Parasites release a variety of molecules that help them to penetrate …

The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory–secretory products

JP Hewitson, YM Harcus, RS Curwen, AA Dowle… - Molecular and …, 2008 - Elsevier
The secretome of a parasite in its definitive host can be considered to be its genome in trans,
to the extent that secreted products encoded by the parasite fulfill their function in the host …

Ancient diversity in host-parasite interaction genes in a model parasitic nematode

L Stevens, I Martínez-Ugalde, E King, M Wagah… - Nature …, 2023 - nature.com
Host-parasite interactions exert strong selection pressures on the genomes of both host and
parasite. These interactions can lead to negative frequency-dependent selection, a form of …

Immunity to Haemonchus contortus and vaccine development

AJ Nisbet, EN Meeusen, JF González… - Advances in …, 2016 - Elsevier
Sheep are capable of developing protective immunity to Haemonchus contortus through
repeated exposure to this parasite, although this immune protection is the result of a …