Three‐dimensional multicellular biomaterial platforms for biomedical application

J Hao, C Qin, C Wu - Interdisciplinary Materials, 2023 - Wiley Online Library
Abstract The three‐dimensional (3D) multicellular platforms prepared by cells or
biomaterials have been widely applied in biomedical fields for the regeneration of complex …

In Situ Fabrication of Constraints for Multicellular Micro‐Spheroids Using Two‐Photon Lithography

M Taale, B Schamberger, F Taheri… - Advanced Functional …, 2024 - Wiley Online Library
photon polymerization is a promising technology for creating complex, microscale 3D
matrices for biomedical and also bioprinting applications. Cancer research provides …

Dynamics of macrophage tumor infiltration

K Adebowale, JL Guerriero, S Mitragotri - Applied Physics Reviews, 2023 - pubs.aip.org
Long-term remission in cancer patients treated with ex vivo bona fide M1-induced
macrophages has been poor, and the reasons behind this are not understood. Injected M1 …

[HTML][HTML] Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density

V Somasundaram, LA Ridnour, RY Cheng, AJ Walke… - Redox Biology, 2022 - Elsevier
Antitumor immune polarization is a key predictor of clinical outcomes to cancer therapy. An
emerging concept influencing clinical outcome involves the spatial location of CD8+ T cells …

Breast cancer immunity: it is TIME for the next chapter

DF Quail, M Park, AL Welm… - Cold Spring …, 2024 - perspectivesinmedicine.cshlp.org
Our ability to interrogate the tumor immune microenvironment (TIME) at an ever-increasing
granularity has uncovered critical determinants of disease progression. Not only do we now …

Self‐Produced O2 CNs‐Based Nanocarriers of DNA Hydrophobization Strategy Triggers Photodynamic and Mitochondrial‐Derived Ferroptosis for Hepatocellular …

MX Liu, YC Liu, YT Cai, YY Gu, YQ Zhu… - Advanced …, 2024 - Wiley Online Library
Hypoxia can aggravate tumor occurrence, development, invasion, and metastasis, and
greatly inhibit the photodynamic therapy (PDT) effect. Herein, carbon nitride (CNs)‐based …

Biofabrication of Modular Spheroids as Tumor‐Scale Microenvironments for Drug Screening

NV Mekhileri, G Major, K Lim, I Mutreja… - Advanced …, 2023 - Wiley Online Library
To streamline the drug discovery pipeline, there is a pressing need for preclinical models
which replicate the complexity and scale of native tumors. While there have been …

In vitro miniaturized tuberculosis spheroid model

S Mukundan, P Singh, A Shah, R Kumar, KC O'neill… - Biomedicines, 2021 - mdpi.com
Tuberculosis (TB) is a public health concern that impacts 10 million people around the
world. Current in vitro models are low throughput and/or lack caseation, which impairs drug …

7-Amino-6H-anthra [9, 1-cd] Isothiazol-6-one-Casein Nanosystem for Live Cell Staining and Augmenting Therapeutic Effectiveness in Triple Negative Breast Cancer

S Khatun, V Kshtriya, N Gour… - ACS Applied Nano …, 2024 - ACS Publications
Triple negative breast cancer (TNBC) causes a significant challenge in oncology due to its
aggressive nature and limited treatment options. This study introduces a promising strategy …

Hypoxia, acidification and oxidative stress in cells cultured at large distances from an oxygen source

N D'Aiuto, J Hochmann, M Millán, A Di Paolo… - Scientific reports, 2022 - nature.com
Hypoxia is a condition frequently encountered by cells in tissues, whether as a normal
feature of their microenvironment or subsequent to deregulated growth. Hypoxia can lead to …