The human placenta project: Funded studies, imaging technologies, and future directions

CL Herrera, MJ Kim, QN Do, DM Owen, B Fei… - Placenta, 2023 - Elsevier
The placenta plays a critical role in fetal development. It serves as a multi-functional organ
that protects and nurtures the fetus during pregnancy. However, despite its importance, the …

[HTML][HTML] A review of feto-placental vasculature flow modelling

J Chappell, R Aughwane, AR Clark, S Ourselin… - Placenta, 2023 - Elsevier
The placenta provides the vital nutrients and removal of waste products required for fetal
growth and development. Understanding and quantifying the differences in structure and …

Understanding abnormal uterine artery Doppler waveforms: a novel computational model to explore potential causes within the utero-placental vasculature

AR Clark, JL James, GN Stevenson, SL Collins - Placenta, 2018 - Elsevier
Abstract Introduction Uterine artery (UtA) Doppler indices are one of the most commonly
employed screening tests for pre-eclampsia worldwide. Abnormal indices appear to result …

Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and hemodynamic factors

HH Allerkamp, S Leighton, T Pole… - American Journal of …, 2023 - journals.physiology.org
Fetal growth throughout pregnancy relies on delivery of an increasing volume of maternal
blood to the placenta. To facilitate this, the uterine vascular network adapts structurally and …

Feeding your baby in utero: how the uteroplacental circulation impacts pregnancy

JL James, LW Chamley, AR Clark - Physiology, 2017 - journals.physiology.org
The utero-placental circulation links the maternal and fetal circulations during pregnancy,
ensuring adequate gas and nutrient exchange, and consequently fetal growth. However, our …

From stem cells to spiral arteries: A journey through early placental development

JL James, AL Boss, C Sun, HH Allerkamp, AR Clark - Placenta, 2022 - Elsevier
Early placental development lays the foundation of a healthy pregnancy, and numerous
tightly regulated processes must occur for the placenta to meet the increasing nutrient and …

Multi-scale modelling of shear stress on the Syncytiotrophoblast: could maternal blood flow impact placental function across gestation?

TC Lee, A Moulvi, JL James, AR Clark - Annals of Biomedical Engineering, 2023 - Springer
The placenta is a critical fetal exchange organ, with a complex branching tree-like structure.
Its surface is covered by a single multinucleated cell, the syncytiotrophoblast, which bathes …

[HTML][HTML] Advances in human placental biomechanics

RP Mayo - Computational and structural biotechnology journal, 2018 - Elsevier
Pregnancy complications are a major clinical concern due to the related maternal and fetal
morbidity. Many are caused through defective placentation, but research into placental …

Blood flow and transport in the human placenta

OE Jensen, IL Chernyavsky - Annual review of fluid mechanics, 2019 - annualreviews.org
The placenta is a multifunctional organ that exchanges blood gases and nutrients between a
mother and her developing fetus. In humans, fetal blood flows through intricate networks of …

Computational modeling of the interactions between the maternal and fetal circulations in human pregnancy

AR Clark, TC Lee, JL James - WIREs Mechanisms of Disease, 2021 - Wiley Online Library
In pregnancy, fetal growth is supported by its placenta. In turn, the placenta is nourished by
maternal blood, delivered from the uterus, in which the vasculature is dramatically …